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Anti-RAT
CD CLUSTERED
ANTIBODIES
RDI Division of Fitzgerald Industries Intl offers a wide line of antibodies. Since no one antibody works best for all applications (flow cytometry, neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below. All products are for in vitro research use only-not for use in or on humans or animals-not for use in diagnostics. Price/availability/specifications subject to change without notice.
cat# RDI-RTCD147-47 $281.00
Presentation: 100ug in 0.2ml (0.5mg/ml) buufer with 0.09% sodium azide
Clone: OX-47
isotype: mIgG1
Immunogen: Rat T blasts
Preparation: purified from tissue culture supernatant by affinity chromatography
Storage: Store 2-8 DEG C undiluted
Use: -flow cytometry 1ug/million cells
-hsitochemistry on aceotne fixed frozen sectons (not sutiable for paraffin sections) 5-10ug/ml
Specificity: The OX-47 antibody reacts with rat CD147 (previously known as OX-47 antigen),a 54-kDa (unreduced)or 65-kDa (reduced)Ig superfamily protein with an unusual single-transmembrane domain. CD147 is the rat homolog of the human EMMPRIN,mouse gp42 or basigin,and the avian neurothelin or HT7 molecules. The CD147 molecule is widely expressed on both hematopoietic and non-hematopoietic cells and tissues. It is expressed on bone-marrow cells,thymocytes,some resting lymphocytes,peritoneal macrophages,and various epithelial cells and is strongly upregulated in activated T and B cells. CD147 has been detected in heart muscle cells,muscle tissues,and endothelium of brain capillaries and kidney tubules. The function of rat CD147 has not been characterized,but it is thought to play a role in cellular adhesion.
References:
1.Paterson,D.J.,W.A.Jefferies,J.R.Green,M.R.Brandon,P.Corthesy,M.Puklavec,a nd A.F.Williams.1987.Antigens of activated rat T lymphocytes including a molecule of 50,000 M r detected only on CD4 positive T blasts.Mol.Immunol.24:1281 -1290.
2.Fossum,S.,S.Mallett,and A.N.Barclay.1991.The MRC OX-47 antigen is a member of the immunoglobulin superfamily with an unusual transmembrane sequence. Eur.J.Immunol.21:671 -679.
3.Barclay,A.N.,M.H.Brown,S.K.A.Law,A.J.McKnight,M.G.Tomlinson,and P.A.van der Merwe.1997.The Leucocyte Antigen FactsBook ,2 nd Edition.Academic Press,San Diego,CA,pp.408 -409.
Hazardous Ingredient:Sodium Azide.Avoid exposure to skin and eyes,ingestion,and contact with heat,acids,and metals.Wash exposed skin with soap and water.Flush eyes with water.Dilute with running water before discharge into plumbing.
For In Vitro resarch Use Only
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RDI Division of Fitzgerald Industries Intl
34 Junction Square Drive
Concord MA 01742-3049
USA
phone (978) 371-6446 or (800) 370-2222
fax (978) 371-2266
EMAIL:antibodies@fitzgerald-fii.com