rev: September 2, 1999
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CD CLUSTERED ANTIBODIES
(anti-Human and others as indicated)
NOTE: 10% Discount on purchases of 3 or more any combination of CD antibodies. Please inquire for bulk or custom formulations (without preservative or carrier).
RDI Divison of researchd Industries Intl offers a wide line of antibodies. Since no one antibody works best for all applications (flow cytometry, neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below. All products are for in vitro research use only-not for use in or on humans or animals-not for use in diagnostics. Price/availability/specifications subject to change without notice.
Catalog#: RDI-CD161-DX $312.00/vial
also FITC conj cat#RDI-CD161-DXFT $438.00/100T
PE conj cat#RDI-CD161-DXPE $500.00/100T
purified (sterile filtered, PBS, no carrier) cat#RDI-CD161-DXP $812.00/0.5mg
Package Size: 100ug purified in 0.2ml (0.5mg/ml) 50mM Tris-Hcl (pH 8.0),
0.15M NaCl and 0.1% sodium azide. (sodium azide is toxic, dilute azide compounds
with copious amounts of water when disposing in drain to avoid accumulation
of explosive deposits- avoid contact with acids.)
Species: mouse IgG1k
CLONE: DX12 Workshop Code:VI, NK12
Activity: Reacts with an 80Kd disulfide-linked homodimer,, type II membrane glycoprotein, also referred to as NKR-P1A. CD161 is expressed on most NK cells and on subsets of CD4+ or CD8+ T cells. Reports indicate that CD161 is expressed preferentially on CD45RO+ T cells, however, it can be found on a subset of thymocytes and fetal liver T cells. It function has not been fully elucidated, but reports indicate that NKR-P1A may serve as a specific receptor for some NK cell targets. May also be useful for NK cell cytotoxicity study. -tissue localization: peripheral blood, thymus
-studies showed this Mab increased the NK-mediated redirected lysis of P815 but not that of K562, cross linking of these mab did not induce NK-cell proliferation, and the treatemnet of NK cells with the Mab induced tyrosine phosphorylation of a protein of 21 kda suggesting that the epsilon chain could be involved in NK-cell activation triggered by NKR-P1 receptor.
Application: -Indirect immunofluorescence cell surface staining (flow cytometry) , Titer for each application
-immunoprecipitation (rIL-2 activated NK cells, dimer of 40kD)|
References: 1) Leucocyte Typing VI, Garland Press, NY 1997
2) J Immunol 153:2417 (1994)
3) J. Exp Med 184:1845 (1996)
4) J. Exp Med 181:1911 (1995)
Ann Review of Immunology 14, 619-48 (1996)
Storage: Store at 4 DEG C.
Precautions:For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.
RDI Divison of researchd Industries Intl
San Jose, 95123 CA Snell ave 658
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