rev: August 22, 2001

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(anti-Human and others as indicated)

RDI Divison of researchd Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.

Mab to Melonoma Associated  Antigen NK1/C3

cat#RDI-PRO10819      $375.00/vial  $338.00/vial 3+

Clone                             NK1/C3

Category                        Mouse monoclonal, ascites

Ig Class                          IgG1

Immunogen                     (isolated from) Human melanoma cells

Clinical Application/

Description/Specificity    NKI/C-3 recognizes a melanoma-associated antigen present in the cytoplasm of melanoma cells and nevocellular nevi, in contrast to most mabs against melanoma-associated antigens present in the membrane, which are not retained after formalin fixation. Therefore, the mab is very useful for paraffin sections in routine pathology. Cross reactivity with carcinoids, medullary carcinomas of the thyroid, and occasionally prostatic, primary breast, avarian, and lung carcinomas may be observed. No reaction is seen with basal cell carcinomas or brain tumors. NKI/C-3 does not react with normal melanocytes or other normal tissues except for mastcells, histiocytes, salivary glands, bronchial glands, pancreatic und prostatic epithelium. In immunoblotting reacts with diffuse protein bands between 25 and 100kd

Positive Control      Prostatic benign hyperplasia

Application                    · Immunoblotting

                                      · Immunohistochemitsry

                  (suitable for paraffin sections ) (proteolytic treatment DESTROYS the epitope)

Antigen Recognized:        Human

Reactivity on Cultured Cell

Lines Tested so far           vRH, VdB, MeWo

Working Dilution             1:5-1:10

Dilution Buffer:                PBS with 1% BSA and 0.1% Na-Azide

Storage                         At 4°C (undiluted) or at - 20 DEGC (aliquots)

Quantity                        1.0 ml

ref: Van Duinen, S.G. e al, Immunohistochemical tools in the diagnosis of Amelonotic Melanoma (1984) Cancer 53:1566-1573.

Suter, L. et al, Immunohistologische Marker for Diagnose und Prognose bel malignen Melanomen (1987) Der Pathologe 8:163-167.

        For In Vitro Research Use Only-Not For Use In Diagnostics

RDI Divison of researchd Industries Intl

San Jose, 95123 CA Snell ave 658


or 408-780-0908

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