rev:   October 1, 2001

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ANTIBODIES  

(anti-Human and others as indicated)

RDI Divison of researchd Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.



DATA SHEET: Mouse anti-human wCD131 (Common Beta Chain)   IL3RB, IL5RB, GM-CSFRB

Catalog#: RDI-CD1313D7   $562.00/vial

Package Size: 500ug purified in 50mM Tris-Hcl (pH 8.0), 0.15M NaCl and 0.1% sodium azide. (sodium azide is toxic, dilute azide compounds with copious amounts of water when disposing in drain to avoid accumulation of explosive deposits-avoid contact with acids.)

Prep: purified

Species: mouse IgG1k

CLONE: 3D7

Workshop Code: Workshop VI, C-65

Activity: Reacts with the 120 kD common B chain (B)of the receptors for human granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-3 (IL-3)   and interleukin-5 (IL-5). The common B chain is   essential for high affinity ligand-binding and signal transduction. The cell-surface receptors, which also include ligand-specific a chains, mediate cytokine regulatory actions of IL-3, IL-5 and GM-CSF which can effect hematopoiesis, inflammation and   immunity. The immunogen used to produce the 3D7 hybridoma was COS cells cotransfected with human IL- 3 receptor a and B chains. B is expressed by a variety of differenct cell types including hematopoietic progenitor cells derived from pluripotent stem cells, monocytes, neutrophils, eosinophils, basophils, endothelial cells, fibroblasts, and Langerhans cells.

Application: -Indirect immunofluorescence cell surface staining , Titer for each application

References: -Leucocyte Typing VI, Garland Press, London

                   -Embo J. 13:5176

Storage: Store at 4 DEG C.

Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics.  It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.

-also available: Biotin labeled cat#RDI-CD1313D7-BT $625.00/0.5mg


RDI Divison of researchd Industries Intl

San Jose, 95123 CA Snell ave 658

USA

or (800) 370-2222

EMAIL:margaret@cellular-research.com

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