rev:  October 1, 2001

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ANTIBODIES  

(anti-Human and others as indicated)

RDI Divison of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.


The Il-2 receptor is a multicomponent complex consisting of three subunits, alpha, beta and gamma, each of which is required for high affinity binding of IL-2 . The ALPHA chain functions primarily in binding of IL-2, whereas the BETA and GAMMA chains contribute to IL-2 binding and are essential to IL-2 induced activation of signaling of pathways leading to T cell growth (ref ). Both IL-4R and IL-7R were initially described as single chain high affinity ligand-binding cytokine receptors. However, it is now well established that the IL-2R gamma chain functions as a second subunit of the high affinity IL-4R and IL-7R receptors (ref 2 & 3) . Consequently the originally described subunits of these latter receptors are now referred to as Il-4 alpha, and IL-7 alpha respectively while the common gamma subunit is referred to as gammac . Although the common chain enhances ligand binding in these three cytokine receptors, it on its own has no capacity to bind these ligands. There is recent evidence that the gammac chain is also a subunit of IL13R (ref 3 & 4)


ref: 1) He, Y.-W, et al, J. Immunol. 154:1596-1605.

2) Goodwin, R.G, et al CELL 60:941-951.

3) Russell, S.M. et al, Science 262:1880-1883

4) Kondo, M. et al, Scinece 262:1874-1877.

see also CD25 (IL2R-alpha) and CD122 (IL-2RBeta)


see also CD clustered antibodies CD25 (human)


RDI Divison of Fitzgerald Industries Intl

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com

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