Human IgG Subclasses Book available through RDI Divison of Fitzgerald Industries Intl

rev: August 5, 2004

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The following book on the IgG Subclass is made available by the permisssion of CLB Reagents (Netherlands). It is for your personal use and may not be reproduced without the permission of CLB Reagents. This material is for information use only and should not be construed as medical advice. We are not responsible for any misprints or error or ommissions. Certain charts ,graphs and table have been ommitted or changed in style (not content) to fit this web site. Please use this information as part of your discussion with your medical professional.

Human IgG Subclasses:

useful diagnostic markers for immunocompetence

Published by CLB,Plesmanlaan 125,

1066 CX Amsterdam,

The Netherlands.

CLB, 1996

Text:Drs A.J. Meulenbroek Dr. W.P. Zeijlemaker

ISBN 90-5267-011-0

The authors are grateful to Dr. A.J. van Houte,Medical Centre Alkmaar, for his expert advice. Thanks are due to their colleagues at CLB: Dr.A.Vlug,Ing.E.J. Nieuwenhuys,Dr.T.A. Out, Prof. Dr.R.C. Aalberse and Drs R.Vis for their valuable support.

TABLE OF CONTENTS (click on each topic of interest to open the section)

1. The immune system in a nutshell

2. + 2.1 + 2.2 IgG subclasses and humoral immunity

2.1 Immunoglobulins and humoral immunity

2.2 Molecular basis of immunoglobulin synthesis

2.3 Properties of human IgG subclasses

2.4 Antibody activity of IgG subclasses

2.5 + 2.5.1 + 2.5.2    Effector functions of IgG subclasses
      Complement activation
   Opsonisation and induction of phagacytosis

3. + 3.1 IgG subclasses in healthy children and adults

Reference values of IgG subclass levels

4. IgG subclasses in disease

4.1 IgG subclass immunodeficiencies, clinical relevance