rev:  December 9, 2002

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CD CLUSTERED ANTIBODIES  

(anti-Human and others as indicated)

NOTE: 10% Discount on purchases of  3 or more any combination of CD antibodies. Please inquire for bulk or custom formulations (without preservative or carrier).

RDI Divison of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (flow cytometry, neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below. All products are for in vitro research use only-not for use in or on humans or animals-not for use in diagnostics. Price/availability/specifications subject to change without notice.


CD91/LRP Antibodies


Mouse anti-human CD91/LRP  antibodies

-2 clones  (see other also other lipoprotein abs)


CATALOG#                 CLONE#                  Workshop    Host         Form        Price

RDI-PRO61066             5A6                               --           mIgG1        purified     $375.00

RDI-PRO61067              8B8                               "            "                 purified     $375.00


Mab to LRP/A2MR(85 kDa)

(low density lipoprotein receptor-related protein/A2-macroglobulin receptor)

cat#RDI-PRO61066    $375.00/vial

Clone                           5A6

Category                       Mouse monoclonal

Form/Purification         Protein A affinity purified

Ig Class                         IgG1

Immunogen                    Human LRP/A2MR

Clinical Application/

Specificity 5A6 specifically reacts with the 85 kDa BETA-chain of human LRP/a 2MR which is expressed in a re-stricted spectrum of cell types (for a recent review cf. Herz & Strickland). A strong immunohistochemical reaction is seen in hepato-cytes, tissue macrophages, subsets of neurones and astro-cytes in the central nervous system, fibroblasts, smooth muscle cells, and monocyte-derived foam cells in athero-sclerotic lesions in the arterial wall. The antibody can also be used for the characterization of a subset of myelo-monocytic subtypes of chronic and acute leukemia (CD 91). Neutralizing effects of clone 5A6 Mab has been reported (Basu et al,2001)

Application

· FACS analysis

· Immunoblotting

· Immunohistochemistry

· Immunofluorescence

Dilution dilute 1:20 with PBS, pH 7.4 for iimmunohistochemistry

Storage/Stability After reconstitution with 1ml distilled water, the antibody is stable for a min 1 year when stored at 4 DEG C For extended storage keep in aliquots at -20 Deg C. Avoid repeated thawing and freezing.

Quantity: 50ug (lyophilized) contains 0.09% sodium azide 0.5% BSA

Reactivity: human, mouse, rabbit,rat, hamster

References:

-Strickland et al. (1990): J Biol Chem 265, 17401-17404.

-Coukos et al (1994): Am J Pathology 144, 383-392

-Rebeck et al (1993): Neuron 11, 575-580

-Gonias et al (1992): Am J Pathology 141, 37-42

-Strickland DK, Kounnas MZ, Argraves WS (1995): LDL receptor-related protein: a multiligand receptor for lipoprotein and proteinase -catabolism. FASEB J 9:890-898

-Herz J and Strickland DK: LRP, a multifunctional scavanger and signalI ng receptor. J. Clin. Invest. 108, 779-784 (2001)

-Bsu S et al, CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70 and calreticulin. Immunity 14 ,303-313 (2001)141

For research use only, not for therapeutic or diagnostic use!

BULK quotes on request


Mab to LRP/A2MR(85 kDa)

(low density lipoprotein receptor-related protein/A2-macroglobulin receptor)

cat#RDI-PRO61067    $375.00/vial

Clone                              8B8

Category                         Mouse monoclonal

Form/Purification           Protein A affinity purified

Ig Class                          IgG1

Immunogen                     Human LRP/A2MR

Clinical Application/

Specificity 8B8 specifically reacts with the 85 kDa beta-chain of human LRP/A2MR which is expressed in a restricted spectrum of cell types. A strong immunohistochemical reaction is seen in hepatocytes, tissue macrophages, subsets of neurones and astrocytes in the central nervous system, fibroblasts, smooth muscle cells, and monocyte-derived foam cells in atherosclerotic lesions in the arterial wall. The antibody can also be used for the characterization of a subset of myelomonocytic subtypes of chronic and acute leukemia (CD91).

Application

· FACS analysis

· Immunoblotting

· Immunohistochemistry

· Immunofluorescence

Species: Human,rabbit,rat,hamster,mouse

Dilution dilute 1:20 with PBS, pH 7.4 for iimmunohistochemistry

Storage/Stability After reconstitution with 1ml distilled water, the antibody is stable for a min 1 year when stored at 4 DEG C. For extended storage, reccomned aliquoting and store at -20 DEG C. Avoid frequent freeze thaw cycles.

Quantity: 50ug (lyophilized) contains 0.09% sodium azide 0.5% BSA

References:

Strickland et al (1990): J. Biol. Chem 265, 17401-17404

Couckos et al (1994):Am J. Pathology 144, 383-392.

Rebeck et al (1993): Neuron 11, 575-580

Gonlas et al (1992):Am J Pathology 141, 37-42

Strickland DK et al (1995):FASEB J. 9:890-898

J Clin Invest 108, 779-784 (2001)

For research use only, not for therapeutic or diagnostic use!


RDI Divison of Fitzgerald Industries Intl

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com

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