rev: March 26, 2002
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CD CLUSTERED ANTIBODIES
(anti-Human and others as indicated)
NOTE: 10% Discount on purchases of 3 or more any combination of CD antibodies. Please inquire for bulk or custom formulations (without preservative or carrier).
RDI Division of Fitzgerald Industries Intl offers a wide line of antibodies. Since no one antibody works best for all applications (flow cytometry, neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below. All products are for in vitro research use only-not for use in or on humans or animals-not for use in diagnostics. Price/availability/specifications subject to change without notice.
CD141 (Thrombomodulin/TM) Antibodies
-see 2 clones below
PRODUCT CODE RDI-CBL584 $375.00
IMMUNIZING ANTIGEN TF1 cell line
FUSION PARTNER X63/Ag.8653 myeloma cell line
SOURCE Tissue culture supernatent
PURIFICATION METHOD Ion-exchange chromatography
SPECIFICITY The antibody recognises the single chain 75kDa polypeptide that is thrombomodulin expressed on human endothelium. The antibody also recognises the soluble form of the antigen.
APPLICATIONS *Flow cytometry
CBL584 Cont'dPRESENTATION The monoclonal is presented as 200ug in 2ml100 tests vial (1ml) in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
STORAGE For use within 1 month of purchase store at +4oC, for long term storage aliquot antibody into small volumes and store at -20oC.
For Research Use Only. Not supplied for use in diagnostic or therapeutic procedures.
cat# RDI-CD141abm-C01 $438.00/0.5ml
Presentation: Tissue culture supernatant with 0.09% sodium azide
Immunogen: Recombinant protein encoding the six repeated EGF domains of human thrombomodulin.
Mol. Wt. of Antigen: 75kDa
Reactivity: human, rat, (others not tested)
Uses: -histochemistry (frozen and paraffin sections) approx 1:25-1:50 for 60 minutes RT
-for paraffin sections, requires boiling tissue sections in 10mM cirate buffer pH6.0 for 10-20
minutes followed by cooling at RT for 20 minutes.
Positive Control: Mesothelioma
Localization: Cell membrane
References: 1. Fink L, et al. Intl J Develop Biol 1993; 37:221
2. Ford VA, et al. J Biol Chem 1992; 267:5446
3. Collins CL, et al. Amer J Pathol 1992; 141(4): 827
Background: Thrombomodulin (TM) is also known as Fetomodulin (FM),
endothelial anticoagulant protein, or glycoprotein P112. Thrombomodulin
contains six repeated domains homologous with epidermal growth factor
(EGF) and an amino terminal domain homologous to lectin-like
protein. Through its accelerated activation of protein C, synthesis
of TM is one of several mechanisms important in maintaining
thrombo-resistance and thus reducing clot formation on the surface
of the endothelial cells. Immunohistochemical staining of
formalin-fixed tissue for TM has been used for the study of a variety
of vascular tumors, meningiomas and choriocarcinomas.
Storage: 2-8 deg c
For Research Use Only
34 Junction Square Drive
Concord MA 01742-3049
phone (800) 370-2222 or
(978) 371-6446 or (800) 370-2222
fax (978) 371-2266
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