rev:January 10, 1997

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ANTIBODIES  

(anti-Human and others as indicated)

RDI Divison of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.

Mouse anti-Na+/K+ alpha 3 subunit Monoclonal ab

cat# RDI-atpa3abm      $406.00/vial

Background: The NA+/K+ Atpase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of NA and K across the cell membrane. The enzyme consists of a large multipass transmembrane catalytic subunit (alpha subunit) and an associated smaller glycoprotein (Beta subunit). Studies indicate that there are three isoforms of the alpha subunit (A1, a2, & A3) and two isoforms of the Beta subunit (B1 & B2) which are encoded by   two multigene families. The alpha 3 subunit has been found in neuronal and to a lesser extent skeletal and cardiac muscle and lung and stomach tissues.

isotype: mIgG1

clone: XVIF9-G10

package: 100ul of diluted ascites fluid with 0.05% sodium azide added

antigen: produced from a fusion of NS-1 myeloma cells and spleen cells from Balb/c mice immunized with canine cardiac microsomes.

Specificity: alpha 3 subunit of NA+/K+ ATPase

                -seen in human, rat, monkey, sheep, canine, rabbit, guinea pig

Use:

         -Western blot:1ug/ml= recognizes approx 110 kDa band which represents the alpha-3                  subunit of the  NA+/K+ ATPase.

         -Immunohistochemistry: 3ug/ml =stains consistent with the plasma membrane localization of            NA+/K+  ATPase.

Storage: Store at -20 DEG C upon receipt. Avoid frequent freeze thaw cycles. Recommend aliquoting. BEFORE OPENING, suggest centrifuging for 1 minute at 1000 RPM to concentrate material in vial.

Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics.

It is the responsibility of the user to comply with all local/state and Federal

rules in the use of this product. We are not responsible for any patent

infringements that might result with the use of or derivation of this product.

RDI Divison of Fitzgerald Industries Intl

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (800) 370-2222 or (201) 584-7093

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com

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