rev:   December 15, 2004

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CYTOKERATIN   ANTIBODIES  

(anti-Human and others as indicated)

RDI Divison of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.


ANTI-CYTOKERATIN 2E

see also clone Ks 2.342.7.4   & RDI-PROGPCK2E


Mab to Cytokeratin 2e   cat#RDI-PRO65177   $344.00/vial

Clone Determination               Ks 2.398.3.1

Category                                  Mouse monoclonal

Immunoglobulin                       Class IgG1

Purification                              Hybridoma culture supernatant

Antigen                                     Synthetic peptide (N-terminal amino acids Nos. 2-23) of human

                                                  cytokeratin 2e (MW 65,852)

Specificity                                 Ks2.398.3.1 represents an excellent marker to study terminal epidermal differentiation. The mab is reactive with epidermal cells in uppermost supra-basal layers including scalp, foot and sole. It recognizes individual cells within epidermis of tongue and mamille (co-localization with cytokeratin 10). It is also reactive on hyperkeratosis of diverse viral and genetic origin.

The mab does not react with palate cytokeratin 2p.

Antigen recognized in species (tested so far) Only reactive on human tissue;

                                                       bovine, mouse, rat, Xenopus laevis are negative.

Application Suitable for           · Immunoblotting (Western)

                                                 · Immunohistochemistry

 Working Dilution                      1:150 for immunohistochemistry

Storage At                                  4°C

Volume                                      1 ml

References

1. Collin C., Moll R., Kubicka S., Ouhayoun J.-P. and Franke W.W. (1992). Characterization of human cytokeratin 2, an epidermal cytoskeletal protein synthesized late during differentiation, Exp. Cell Res. 202: 132-141.

2. Langbein L., Moll I., Prätzel S., Moll R., Franke W.W. Specific expression of cytokeratin 9 and 2e in cutaneous disorders of variant body sites (manuscript in preparation).

3.Swensson O, Langbein L, McMillan JR, Churchill LJ, Leigh IM, McLean WHI, Lane EB, Eady RAJ. Specialized keratin expression pattern in human ridged skin as an adaption to high physical stress. Br.J.Dermatol. 139, 767-775 (1998)

For Research Use Only


RDI Divison of Fitzgerald Industries Intl

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com

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