rev:  May 25, 2005

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CYTOKERATIN   ANTIBODIES  

(anti-Human and others as indicated)

RDI Divison of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.


ANTI-TENASCIN


Mab to Tenascin

cat#RDI-TENASNabm    $438.00/100ug      

      RDI-TENASNabmX  $688.00/200ug

Clone T2H5


Category Mouse monoclonal


Form :purified IgG


Ig Class IgG1


Antigen Isolated from human mammary tumor cells


Introduction Tenascin is a large hexameric extracellular matrix molecule with oncofetal properties. During embryonic development the protein is expressed in many parenchymatous organs, where it appears to have a regulating role in epithelial differentiation. In most mature tissues the expression is restricted to the papillary dermis, but reappears in tissue regeneration and repair and in neoplasia. In basal cell carcinoma two forms (Mr 210,000 and 300,000 kDa) of tenascin can be found, in contrast to normal skin and fibroblasts, where one form predominantly exists (Mr 300,000 kDa).


Clinical Application/Specificity Detects extracellular matrix glycoprotein Tenascin in connection with gliomas, mammary tumors and in proliferative skin diseases (psoriasis, skin tumors)


Recommended for 1: 5 - 1:20

Application :RIA, ELISA

                  :Immunoblotting (Western)

                 : Immunohistochemistry

                 : Suitable for frozen sections

                  :parrafin sections (with high temperature unmasking)

Antigen Recognized in species tested so far: Human


Working Dilution : 2-4ug/ml


Dilution Buffer PBS (1% BSA and 0.09% Na-Azide)


Incubation Time 1 h at RT


Storage At 4°C


Volume : 100ug

References:

A.A. Verstraeten, E.J. Mackie, Ph.C. Hageman, J. Hilgers, D.J. Schol, G.J. De Jongh and J. Schalkwijk: Tenascin expression in basal cell carcinoma. British Journal of Dermatology (1992) 127, 571-574.

Bosman, F.T. et al. Progr Histochem, Cytochem 24(4) 1-92 (1992)

Koukoulis, G.K. et al, Human Pathol., 222,, 636-643 (1991)

For research use only. Not supplied for use in human diagnostic or therapeutic procedures


RDI div of Fitzgerald Industries Intl

(Research Diagnostics Inc)

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (800) 370-2222

      or (978) 371-6446 or (800) 370-2222

fax   (978) 371-2266

email: sales@researchd.com

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