rev: October 4, 2001
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CD CLUSTERED ANTIBODIES
RDI Divison of Fitzgerald Industries Intl offers a wide line of antibodies. Since no one antibody works best for all applications (flow cytometry, neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below. All products are for in vitro research use only-not for use in or on humans or animals-not for use in diagnostics. Price/availability/specifications subject to change without notice.
Catalog#: RDI-RTCD59-TH9 $500.00/vial
Package Size: 500ug in 1ml 10mM phosphate buffer, pH7.4 with 150mM NaCl and 0.09% NaN3
Species: mouse IgG1k
Antigen: membrane attack complex-inhibitory proteins from rat erythrocyte membranes
Purification: from tissue culture supernatant by affinity chromatography
Activity: Reacts with rat CD59 ,a 21kd glycosyl- phosphatidyl inositol-anchored cell surface glycoprotein of the Ly-6 superfamily. CD59 is expressed by many types of non-hematopoietic cells. In the rat hematopoietic system, CD59 has been detected on erythrocytes, monocytes, and some lymphocytes, but not on platelets. Soluble CD59 is found in body fluids and urine. CD59 is a complement regulatory protein which acts late in the complement cascade to prevent formation of the membrane attack complex (MAC). Therefore, CD59 is one of several proteins whose function is to protect host tissue from complement attack. Rat CD59 binds rat and human complement components and inhibits cytolysis mediated by complement from multiple species. CD59 has also been suggested to be a ligand for CD2 and to participate in T-cell costimulation.
Application: -Indirect facs (1ug/million cells
-histochemistry:acetone fixed frozen sections (1-5ug/ml).
-blocking of ligand binding
be determined for each application
Storage: Store at 4-8 Deg C (short term)
ref: Biochem .J. (1992) 284:169-176
J. Immunol (1996) 156:3696-3703
Immunology (1993) 80:439-444
Immunology (1997) 90:640-646
Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics.
also available:FITC conjugated: cat#RDI-RTCD59-TH9FT $625.00/0.5mg
34 Junction Square Drive
Concord MA 01742-3049
phone (978) 371-6446 or (800) 370-2222
fax (978) 371-2266