rev: October 17, 2001

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Anti-RAT
CD CLUSTERED ANTIBODIES  

RDI Division of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (flow cytometry, neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below. All products are for in vitro research use only-not for use in or on humans or animals-not for use in diagnostics. Price/availability/specifications subject to change without notice.

Anti-RAT  CD40  Antibodies

DATA SHEET:Hamster anti mouse/Rat CD40 ( IgE Fc Receptor), monoclonal

Catalog#: RDI-MCD40-HM40     $312.00/100ug with azide

               RDI-mCD40-HM40X    $625.00/1pkg

Package Size: 0.1mg purified ab in 0.2ml buffer with 0.09% sodium azide.

Supplied: purified hamster monoclonal

Clone: HM40-3

Ig Isotype: Armenian Hamster IgM

Reactivity: Reacts with the murine CD40 molecule, a 40-50 kDa glycoprotein expressed on B cells, follicular dendritic cells, thymic epithelium and interdigitating cells in the T cell zones of secondary lymphoid organs. The CD40 molecule has a central role in B cell growth and differentiation:Ligation of CD40 is reported to be an important signal in B cell survival. Furthermore, signaling through CD40 in combination with IL-4 reportedly induces immunoglobulin isotype switching and secretion of IgE.

-Plate bound or soluble HM40-3 antibody stimulates spleen cells to proliferate in vitro. This antibody also induces spleen B cells to express the co-stimulatory molecule CD86. Clone HM40-3 has been demonstrated to inhibit the binding of soluble gp39, the CD40 Ligand to soluble CD40 and to cell surface CD40.

-Also cross reacts with simialr opulations of Lewis, Sprague-Dawley and LOU rat leukocytes.

Uses: -indirect flow cytometry

         -blocking of ligand binding (azide free)

        -B cell activation

         -Lewis rat B cells

        (for mouse histochemistry, recommend clone 3/23)

Storage: Store at 4 Deg C.

Ref: Immunol Today 13:431-433

        Nature 367:425-428

       J. Immunol 165:4202-4208 (2000)

Precautions: For In vitro research Use Only. Not for use in or on humans or   animals or for diagnostics. Sodium azide may form explosive   compounds in presence of heavy metals or under acidic   conditions. Flush drains with copious amounts of water to   prevent buildup of explosive compounds.  

It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.

also available: Fitc labeled: cat#RDI-mcd40-FT $625.00/0.5mg-All products are for in vitro research use only-Not for

-reacts with aremenian hamster IgM monoclonal antibodies. tested in ELISA and flow use.

-clone G188-2

-isotype mouse (Balb/c) IgG1

-antigen aremenian hamster IgM

-also available: FITC conjugated cat#RDI-2NDHAMIGMX-FT $406.00/0.5mg

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RDI Division of Fitzgerald Industries Intl

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com