rev: December 15, 1998

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Anti-RAT
CD CLUSTERED ANTIBODIES  

RDI Division of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (flow cytometry, neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below. All products are for in vitro research use only-not for use in or on humans or animals-not for use in diagnostics. Price/availability/specifications subject to change without notice.

Anti-RAT  CD2  Antibodies

Catalog#: RDI-RTCD2-OX34    $375.00/vial     $344.00/vial 3 +    Bulk on request

Package Size: 0.5mg in 1.0ml PBS with 0.1% NaN3

Species: mouse IgG2ak

CLONE: OX-34

Immunogen: Rat T blasts from mixed lymphocyte reactions

Activity: Reacts with CD2 (LFA-2), a member of the immunoglobulin superfamily. In the rat, CD2 is expressed on thymocytes, T lymphocytes in spleen and lymph node, dendritic epidermal T cells,splenic macrophages and NK cells but not on B cells, intestinal intraepithelial lymphocytes or peritoneal and liver macrophages. CD2 can associate with the T- cell receptor complex, and it may function in both intracellular adhesion and signal transduction. In the rat, CD48 is the only known ligand for CD2.

Clone OX-34 ab binds to the extracellular portion of CD2, and it blocks the binding of CD2 to CD48. While clone OX34 ab does not activate T cells, it partially blocks activation by immobilized MABs to CD3 (clone G4.18) and alpha/beta T-cell receptor (clone R73) and it partially inhibits allogenic mixed lymphocyte reactions. Morever, in vivo administration of OX-34 antibody depletes peripheral T cells and prevents allograft rejection.

Application: -Indirect fluorescence (approx 1ug/1M cells)

                     -histochemistry on acetone fixed frozen   sections and paraffin sections

                      -immunoprecipitation

                     -blocking in vitro T cell responses*

                     -in vivo depletion *

                               *azide free material

                      -titers must be determined for each application

Storage: Store at 4 Deg C

ref: J. Exp Med 165:368-380

      Transplantation 59:85-90

      EMBO J. 12:4945-4954

      J. Exp med 162:117-127

Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics.

FITC labeled cat#RDI-RTCD2-OXFT $625.00/0.5mg

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RDI Division of Fitzgerald Industries Intl

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com