rev: July 15, 1999

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ANTIBODIES  

(anti-Human and others as indicated)

RDI Divison of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.

Shows neurons that are stained immunohistochemically in AD brain. You can also see a senile plaque (unstained)

DATA SHEET:   Goat anti-Presenilin-1 Peptide (14-33)

Background: The presenilin-1 gene has recently been discovered on chromosome 14 and is responsible for an early onset form of Alzheimer's disease that accounts for 70-80% of the inherited forms of Alzheimer's. It is a membrane protein that has a region where at least seven mutations have been identified in family members with Alzheimer's disease. The 14-33 peptide sequence corresponds to the N-terminus of this protein which is exposed to the extracellular region.

The gene sequence of presenilin-1 does not match any known human gene sequences, therefore its identify and function remain unknown.

Catalog#: RDI-PRESEN1abG

Price: $312.00/0.25ml   $469.00/0.5ml   $938.00/ml 1 or more

Package Size: neat serum

Species: Goat

Antigen: synthetic peptide corresponding to amino acids 14-33 of the N terminus of the human Alzheimer's disease presenilin-1 protein (PS-1)

sequence: A Q M S E D N H L S N T N R S Q N D N R  (cat#RDI-PRESEN1-CPX  $469.00/1mg)

Specificity: specific for residues 14-33 on the N- terminus of presenilin-1

Optimal titers must be determined empirically by each end user.

USE: Elisa using immunizing peptide 1:5000

         histochemistry (pfa fixed frozen) 1:1K

        formalin fixed paraffin 1:100


ref: Nature 357:751-760, 1995


Storage: Store 4 DEG c (short term) or -20 DEG C long term. Recommend aliquot and store at -20 DEG C . Avoid frequent freeze thaw cycles.

Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com

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