rev: April 8, 1998
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(anti-Human and others as indicated)
RDI Divison of Fitzgerald Industries Intl offers a wide line of antibodies. Since no one antibody works best for all applications (neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.
Background: Beta Amyloid protein is deposited inassociation with extracellular neufibrillary TANGLES, within senile plaques (diffuse and classical) and in vessel walls in a number of neurological diseases. These include Alzheimers disease, down's syndrome, hereditary cerebral hemorrhage with amyloidosis (Dutch type) and in the Guam Parkinson-Dementia complex.Immunohistochemistry is more sensitive than other methods fordetection of the beta amyloid protein.
Batch: see batch sheet
Package Size: 1ml lyophilized (tissue culture supernatantcontaining 15mM sodium azide). Reconstitutewith 1ml distilled water.
Isotype: mouse IgG1
Antigen: synthetic peptide representing a site on the beta-amyloid
Activity: Positive staining can be observed in senile plaque cores, plaque periphery and diffuse plaques. In some cases staining can be seen in vessel walls and in extracellular neurofibrillary tangles in Alzheimer's disease.
Application -frozen sections and paraffin sections( pretreated with formic acid, after immersing sections in ethanol/hydrogen peroxide, incubate sections in 98-100% formic acid for 3 minutes then rinse in distilled water )
Initial dilution: 1:50 , stain 60 minutes room temp, Visualize ABC methods.
Storage: Store at 4 Deg C or below. Store reconstituted material in aliquots at -20 DEG C. Avoid frequent freeze thaw cycles.
ref: American Journal of Pathology 133:150-162(1988)
Human Pathology 19:214-222 (1988)
Neuroscience Letters. 68:252-256 (1986)
Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostic It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.
RDI Divison of Fitzgerald Industries Intl
34 Junction Square Drive
Concord MA 01742-3049
phone (978) 371-6446 or (800) 370-2222
fax (978) 371-2266
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