rev: July 15, 1999
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(anti-Human and others as indicated)
RDI Divison of Fitzgerald Industries Intl offers a wide line of antibodies. Since no one antibody works best for all applications (neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.
Cat. No. RDI-ASYNUCabG $315.00/0.25ml
-A goat antiserum to a synthetic peptide that corresponds to amino acids 116 - 131 of the C-terminus of the Parkinson disease Alpha-synuclein protein is currently available. The Alpha-synuclein gene was discovered on chromosome 4 and is responsible for early-onset autosomal dominant Parkinsons disease. It is an abundant protein whose major site of expression is in the nervous system. Human ALPHA-synuclein is also known to be a precursor of the non- -amyloid component protein (NACP) of Alzheimers disease where one of its fragments associates amyloid deposits.
-The function of this gene product is currently unknown, but it is being
shown to be associated with other neurodegenerative diseases, such as dementia
with Lewy bodies and multiple-system atrophy. This antiserum has been shown
to be immunoreactive to the ALPHA-synuclein immunizing peptide by ELISA.
Currently, this antibody has been shown to immunolabel Lewy bodies in Parkinson
brains using formalin-fixed, paraffin-embedded sections. This antibody should
be a valuable tool for scientists who will be working to discover the function
of this protein in normal individuals and its role in Parkinsons and
other neurodegenerative diseases.
-Spillantini M. G., et al. A-synuclein in Lewy bodies. Nature 388: 839-840, 1997.
-Gai, W. P., et al. Multiple-system atrophy: a new A-synuclein disease. Lancet 352: 547-548, 1998.
DESCRIPTION: ALPHA -Synuclein C-terminal Peptide Antiserum
PRODUCT NO: RDI-ASYNUCabG $312.00/0.25ml
ANTIBODY HOST: Goat
IMMUNOGEN: Synthetic peptide corresponding to amino acids 116-131 of the C-terminus of the human ALPHA -Synuclein protein.
Antigen sequence: M P V D P D N E A Y E M P S E E (cat#RDI-ASYNUC-CPX $469.00/1mg)
FORM: Whole antiserum
TITER: Recommended dilutions based of neat serum:
- ELISA using immunizing peptide: approx 1:1,000
- IHC formalin-fixed, paraffin sections: approx 1:300
- IHC paraformaldehyde-fixed, frozen sections: n/d
-Western Blots: n/d
SPECIFICITY:Specific for residues 116-131 on the C-terminus of human ALPHA-Synuclein Protein
STORAGE: 4° C short term; -20° long term
FOR RESEARCH AND MANUFACTURING USE ONLY.
Goat ALPHA-Synuclein Antiserum
Parkinson disease brain showing immunohistochemical staining of Lewy body at 1:300 dilution in formalin-fixed, paraffin-embedded section of substantia nigra.
RDI Divison of Fitzgerald Industries Intl
34 Junction Square Drive
Concord MA 01742-3049
phone (978) 371-6446 or (800) 370-2222
fax (978) 371-2266
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