rev: October 3, 2001
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CD CLUSTERED ANTIBODIES
RDI Divison of Fitzgerald Industries Intl offers a wide line of antibodies. Since no one antibody works best for all applications (flow cytometry, neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below. All products are for in vitro research use only-not for use in or on humans or animals-not for use in diagnostics. Price/availability/specifications subject to change without notice.
Catalog#: RDI-MCD74abm-IN $500.00/1pkg
Package Size: 0.5mg in 1.0ml 50mM Tris-HCL pH 8.0 with 150mM NaCl
and 0.1% sodium azide.
Supplied: purified by affinity chromatography
Ig Isotype: Rat IgG2bk
Reactivity: -The IN-1 antibody reacts with CD74, the MHC Class II associated invariant chain (Ii), expressed in I-A+ cell populations. Although it is predominantly expressed intracellularly, it has also been detected on the cell surface of some B-cell lines and at low levels on a small number of B lymphocytes. In the mouse, alternatively spliced transcripts encode 31kda amd 41kda isoforms, and the cell surface CD74 has a chondroitin sulfate side chain which allows it to interact with CD4. CD74 is directly involved in the intercellular transport ofMHC class II molecules and antigen presentation,and it affects the maturation of T and B lymphocytes.
Uses: -flow cytometry (<1ug/1M cells), on permeabilized cells-
-acetone fixed frozen sections
-zinc fixed paraffin sections (not recommended for formalin fixed)
-Nature 299:644-645 (1982)
-Cell 74:257-268 (1994)
-J. Exp Med 177:1699-1712 (1993)
-J.Exp med 179:681-694 (1994)
-Cell 72:635-648 (1993)
-Eur J Immunol 26:3185-3193 (1996)
-Science 280:450-453 (1998)
-J. Immunol 146:920-927 (1991)
Storage: Store at 4 Deg C.
Precautions:For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics. Sodium azide may form explosive compounds in presence of heavy metals or under acidic conditions. Flush drains with copious amounts of water to prevent buildup of explosive compounds.
It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.
also available FITC conjugated: cat#RDI-MCD74-INFT $562.00/0.5mg
34 Junction Square Drive
Concord MA 01742-3049
phone (978) 371-6446 or (800) 370-2222
fax (978) 371-2266