rev:  October 3, 2001

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Anti-MOUSE
CD CLUSTERED ANTIBODIES  

RDI Division of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (flow cytometry, neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below. All products are for in vitro research use only-not for use in or on humans or animals-not for use in diagnostics. Price/availability/specifications subject to change without notice.

Anti-MOUSE  CD48  Antibodies

(see monoclonal and goat polyclonal below)

DATA SHEET:  Hamster anti mouse CD48 (BCM1) monoclonal

Catalog#: RDI-MCD48-HM                         $281.00/100ug

                 RDI-MCD48-HMFT                    $312.00/100ug FITC

                 RDI-MCD48-HMX (azide free)   $625.00/0.5mg (sterile filtered, azide free) BULK on quote

Package Size: in Tris or PBS(azide free) with 0.09%   NaN3

Clone: HM48-1

Ig Isotype: armenian Hamster IgG, group 1

Immunogen: Mouse T lymphphoma MBL-2

Reactivity: Reacts with CD48 (previously known as BCM1 in mice, BLAST-1 in human and OX-45 in rat), which is the major ligand of CD2 in mouse. CD48 is a GPI anchored membrane of the Ig superfamily and is widely distributed on leukocytes, but not on non- hematopoietic cells. Clone HM48-1 mAb blocks binding of soluble CD2 to CD48 bearing cells, inhibits spleen cells proliferative responses to mitogens, augments the proliferative response of spleen cells when cross linked with anti- CD3E mabs, and inhibits priming of CTL in vitro. In vivo administration of HM48-1 antibody can prolong survival of cardiac allografts, an effect which is greatly enhanced by the addition of anti-CD2 Mab clone 12-15. This antibody does not cross- react with rat leukocytes.

USE: -flow cytometry(<1ug/1M cell

         -immunoprecipitation

         -blocking (no azide preparation)

ref: -J. Exp Med 176:1241-1249 (1992)

      -J. Exp Med 179: 341-346 (1994)

      -J. Exp Med 171:2115-2130 (1990)

Storage: Store at 4-8 DEG C

Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics. Sodium azide may form explosive compounds in presence of heavy metals or under acidic conditions. Flush drains with copious amounts of   water to prevent buildup of explosive compounds.

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RDI Division of Fitzgerald Industries Intl

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com