rev:  October 3, 2001

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Anti-MOUSE
CD CLUSTERED ANTIBODIES  

RDI Division of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (flow cytometry, neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below. All products are for in vitro research use only-not for use in or on humans or animals-not for use in diagnostics. Price/availability/specifications subject to change without notice.

Anti-MOUSE  CD21 Antibodies

Catalog#:   RDI-MCD21-7G6         $531.00/1pkg

Package Size: 0.5mg in 1ml (0.5mg/ml) in Tris-Hcl with 0.09%NaN3

Clone: 7G6

Ig Isotype: rat IgG2b

Antigen: Purified CR1

Reactivity: CLone 7G6 antibody recognizes an epitope shared by the 150kDa CD21 and the 190kDa CD35 molecules. both of these   molecules are membrane proteins resulting from the alternative splicing of mRNA transcribed from the Cr2 gene. In the mouse, CD21 and CD35 are expressed on the majority of peripheral B cells, on the majority of resident peritoneal macrophages, and on peripheral blood granulocytes after treatment with N-formyl-Met-Leu-Phe, but not on thymocytes, T cells, erythrocytes or platelets. This antibody has been reported to inhibit rosette formation by C3d bearing sheep erythrocytes and to down-regulate mouse CD21/CD35 expression upon in vivo application, thus inhibiting primary antibody responses to immunization. Clone 7G6 ab recognizes an epitope on CD35 distinct from the epitope recognized by anti-mouse CD35 clone 8C12 and does not block the binding of clone 8C12 to mouse CD35.

USE: -flow cytometry(<1ug/1M cells)

          -histochemistry (acetone fixed frozen sections

           -western blot

          -immunoprecipitation

          -function blocking (azide free)

ref:

-J. Immunol 144:3581-3591

-J. Immunol 140:3066-3072

-J. Immunol 147:224-230

Storage: Store at 4

Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics. Sodium azide may form explosive compounds in presence of heavy metals or under acidic conditions. Flush drains with copious amounts of water to prevent buildup of explosive compounds.

also available: FITC labeled        cat#RDI-MCD21-7G6-FT   $625.00/0.5mg

azide free/sterile                           cat#RDI-MCD21-7XP         $625.00/0.5mg

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RDI Division of Fitzgerald Industries Intl

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com