rev: September 9, 2003
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Anti-MOUSE
CD CLUSTERED
ANTIBODIES
RDI Division of Fitzgerald Industries Intl offers a wide line of antibodies. Since no one antibody works best for all applications (flow cytometry, neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below. All products are for in vitro research use only-not for use in or on humans or animals-not for use in diagnostics. Price/availability/specifications subject to change without notice.
Anti-MOUSE CD134 (OX40)
Antibodies
Catalog#: RDI-MCD134-OX8 $469.00/vial
Package Size: 500ug purified in 1ml PBS pH 7.4 with 0.1% sodium azide.
(sodium azide is toxic, dilute azide compounds with copious amounts
of water when disposing in drain to avoid accumulation of explosive
deposits-avoid contact with acids.)
prep: purified by Protein G from tissue culture supernatant
Species: Rat IgG1
CLONE: OX-86
Immunogen: Cho cells transfected with murine OX40
Fusion Partner: spleen cells from immunized AO rats were fused with cells
of the mouse NS1 myeloma cell line
Activity: The OX-86 Mab reacts with the OX-40 antigen (CD134) also known
as OX-40 receptor, which is a 50kda type I membrane glycoprotein that
belongs to the NGFR/TNFR superfamily. Mouse CD134 is expressed on
activated CD4+ and CD8+ T lymphocytes and has been shown to be the
sole receptor for the OX-40 ligand (OX-40L). OX-40 antigen provides
a costimulatory signal that indices T cells to proliferate in
a CD28-independent manner. The OX-86 Mab stains both CD4+ and CD8+ activated
T cells, and this expression pattern has been confirmed using OX-40L-Ig fusion
protein. CD134 was also detected, using OX-86Mab, on B cells after
stimulation with Anti-IgM plus CD40Mab clone HM40-3. OX-86 Mab does
not block binding of OX-40L to OX-40 and it stimulates T cell
proliferation mildly.
Application: -Indirect immunofluorescence cell surface staining , approx
1ug/million cells Titer for each application
-western
blot
ref: Eur J Immunol 26:1695-1699 (1996)
J Immunol 162:7058-7066 (1999)
EMBO J. 13:3992-4001 (1994)
Storage: Store at 4 DEG C .
Precautions: For In vitro research Use Only. Not for use in or on humans
or animals or for diagnostics. It is the responsibility of the
user to comply with all local/state and Federal rules in the use of this
product. We are not responsible for any patent infringements that might result
with the use of or derivation of this product.
-also available:
-also available:Biotin labeled cat#RDI-MCD134-86BT $562.00/0.5mg
It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.
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RDI Division of Fitzgerald Industries Intl
34 Junction Square Drive
Concord MA 01742-3049
USA
phone (978) 371-6446 or (800) 370-2222
fax (978) 371-2266
EMAIL:antibodies@fitzgerald-fii.com