rev:      February 25, 2005

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(anti-Human and others as indicated)

RDI Divison of researchd Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.

Guinea Pig Pab to TIP47 / PP17

Cat#RDI-PROGP30        $406.00

Category                          Guinea pig polyclonal

Form/Purification            Whole antiserum

Antigen                            Synthetic peptide of TIP47 N-terminus (aa 1 - 16)

Description/Specificity  TIP47 (synonymous with PP17b1) has been described as cargo protein involved in the trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex (cf. Diaz & Pfeffer). The protein has been localized in milk fat globule membranes of human and bovine origin. PP17b1 has been described also as a placental protein. Increased amounts of PP17b1 are secreted into circulation of cervix carcinoma patients. After radical surgery PP17b1 serum levels are decreased (cf. Than et al.). The protein probably is significant as an oncodevelopmental marker. TIP47 or PP17b1 show about 40% sequence homology to adipophilin. The GP30 antiserum, however, does not cross-react with adipophilin and perilipin.

Antigen Recognized  in Species        Human, bovine

(tested so far)

Reactivity on Cultured  Cell Lines        3T3 cells

(tested so far)

Application Suitable for

· immunohistochemistry on frozen tissue; paraffin sections after microwave treatment

· immunoblotting (Western)

Working Dilution 1:100 - 200 for immunohistochemistry

                             1:1000 for immunoblotting (Western); ECL

Incubation Time     1 h at RT for immunohistochemistry

Storage                   At 2-8°C

Quantity                 100 µl (contains 0.09% NaN3)


1. Diaz E & Pfeffer SR (1998): TIP47, a cargo selection device for mannose 6-phosphate receptor trafficking. Cell 93, 433-443.

2. Than NG, et al, Cloning and sequencing of human oncodevelopmental soluble placental tissue protein 17 (PP17), homology with adipophilin and the mouse adipose differentiation-related protein. Tumor Biol 20, 184-192 (1999)

For Research Use Only

See also  anti-guinea pig secondary antibodies

RDI Divison of researchd Industries Intl

San Jose, 95123 CA Snell ave 658


or (800) 370-2222

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