rev: 5/15/2008
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ANTIBODIES
(anti-Human and others as indicated)
RDI Division of Fitzgerald Industries Intl offers a wide line of antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.
Mab to LRP/A2MR(85 kDa) human, mouse, rabbit,rat, hamster
(low density lipoprotein receptor-related protein/A2-macroglobulin receptor)
cat#RDI-PRO61066, new cat#: 10R-L107b $412.50/vial
Clone 5A6
Category Mouse monoclonal
Form/Purification Protein A affinity purified
Ig Class IgG1
Immunogen Human LRP/A2MR
Clinical Application/
Specificity 5A6 specifically reacts with the 85 kDa BETA chain LRP/alpha 2MR which is
expressed in a restricted spectrum of cell types (for a recent review cf. Herz & Strickland). A
strong immunohistochemical reaction is seen in hepato-cytes, tissue macrophages, subsets of
n eurones and astro-cytes in the central nervous system, fibroblasts, smooth
muscle cells, and monocyte-derived foam cells in athero-sclerotic
lesions in the arterial wall. The antibody can also be used for the characterization of a
subset of myelo-monocytic subtypes of chronic and acute leukemia (CD 91).Neutralizing effects of clone 5A6 Mab has been reported (Basu et al,2001)
Reactivity: human, mouse, rabbit,rat, hamster
Application · FACS analysis
· Immunoblotting
· Immunohistochemistry
· Immunofluorescence
. receptor binding assays
Dilution dilute 1:20 with PBS, pH 7.4 for iimmunohistochemistry
Storage/Stability After reconstitution with 1ml distilled water, the antibody is stable
for a min 1 year when stored at 4 DEG C
Quantity: 50ug (lyophilized) contains 0.09% sodium azide 0.05% BSA
References: Strickland et al (1990): J. Biol. Chem 265, 17401-17404
Couckos et al (1994):Am J. Pathology 144, 383-392.
Rebeck et al (1993): Neuron 11, 575-580
Gonlas et al (1992):Am J Pathology 141, 37-42
Strickland DK et al (1995):FASEB J. 9:890-898
Herz J and Strickland DK: LRP, a multifunctional scavanger and signaling
receptor. J. Clin. Invest. 108, 779-784 (2001)
-Bsu S et al, CD91 is a common receptor for heat shock proteins gp96, hsp90,
hsp70 and calreticulin. Immunity 14 ,303-313 (2001)141
For In Vitro Research Use Only-Not For Use In Or On Humans or Animals-Not For
Diagnostics
RDI Division of Fitzgerald Industries Intl
phone (978) 371-6446 or (800) 370-2222
fax (978) 371-2266
EMAIL:antibodies@fitzgerald-fii.com
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