rev:   5/15/2008

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  ANTIBODIES

(anti-Human and others as indicated)

RDI Division of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.

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Mab to LRP/A2MR(515 kDa)

CD91 (low density lipoprotein receptor-related protein/A2-macroglobulin receptor)

cat#RDI-PRO61065, new cat#: 10R-L107a     $412.50/vial

-also available Biotin conjugated cat#RDI-PRO61565, new cat#: 61R-L107aHUBT  $525.00/0.25ml

Clone                            8G1

Category                       Mouse monoclonal

Form/Purification           Protein A affinity purified

Ig Class                         IgG1

Immunogen                    Human LRP/A2MR

Clinical Application/

8G1 specifically reacts with the 515 kDa A-chain of human LRP/alpha AMR which is expressed in a restricted spectrum of cell types (for a recent review cf. Herz & Strickland). A strong immunohistochemical reaction is seen in hepatocytes, tissue macrophages, subsets of neurones and astrocytes in the central nervous sys-tem, fibroblasts, smooth muscle cells, and monocyte-derived foam cells in atherosclerotic lesions in the arterial wall. The antibody can also be used for the characterization of a subset of myelo-monocytic subtypes of chronic and acute leukemia (CD 91).

Application                 · FACS analysis

                                  · Immunoblotting

                                  · Immunohistochemistry

                                  · Immunofluorescence

Dilution                       dilute 1:20 with PBS, pH 7.4 for iimmunohistochemistry

Storage/Stability         After reconstitution with 1ml distilled water, the antibody is stable

                                  for a min 1 year when stored at 4 DEG C

Quantity:                   50ug (lyophilized) contains 0.05% BSA in PBS pH7.4

References:               Strickland et al (1990): J. Biol. Chem 265, 17401-17404

                                 Couckos et al (1994):Am J. Pathology 144, 383-392.

                                 Rebeck et al (1993): Neuron 11, 575-580

                                 Gonlas et al (1992):Am J Pathology 141, 37-42

                                 Strickland DK et al (1995):FASEB J. 9:890-898

                               Herz J and Strickland DK: LRP, a multifunctional scavanger and signaling receptor. J. Clin. Invest. 108, 779-784 (2001)


For In Vitro Research Use Only-Not For Use In Or On Humans or Animals-Not For Diagnostics

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RDI Division of Fitzgerald Industries Intl

(Research Diagnostics Inc)

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

email: sales@researchd.com

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