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  ANTIBODIES  

(anti-Human and others as indicated)

RDI Division of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.

Polyclonal Antibody to Neurokinin A/Substance K

Cat#RDI-PRO16051          $688..00

Category                           Rabbit polyclonal

Form/Purification             Undiluted serum (lyoph.)

Immunogen                        Neurokinin A/Substance K , conjugated to BSA

Description/ Specificity Neurokinin A/Substance K represents a member of the tachykinin family of peptides. Neurokinin A, which arises by cleavage of the substance P precursor, occurs in neurons in the central and  peripheral nervous systems, and is particularly numerous in the gastrointestinal tract. The biological actions of neurokinin A are similar to those of substance P, and include vasodilation and stimulation of smooth muscle contraction. Absorption with 10-100 µg NKA per ml diluted antiserum abolishes the staining, while substance P does not.

Positive Control            Formalin-fixed paraffin sections of rat colon

Species tested so far      Human, pig, rat; fish

Application                   o Immunofluorescence

                                      o Immunohistochemistry

                                       o Suitable for frozen and paraffin sections

Reconstitution              Dissolve the antiserum in 50 - 100 µl distilled water, and dilute further in 0.1 M PBS with 1% BSA and 0.1% NaN3.

Working Dilution         1:400 - 1:800 (PAP)

                                     1:200 - 1:400 (immunofluorescence microscopy using FITC) with overnight incubation at 2-8°C.

Storage                        At 2-8°C (lyoph.) or at -20°C (aliquots)

Quantity /Volume       50 µl (lyoph.)

Reference

Karila P et al: Projections and actions of tachykininergic, cholinergic, and serotoninergic neurones in the intestine of the Atlantic cod. Cell Tissue Res 291, 403-413 (1998).

Hauser-Kronberger et al: Neuropeptides in the human penis. An immunohistochemical study. J Andrology 15, 510-520 (1994).

Schmidt P et al: Substance P and Neurokinin A are codistributed and colocalized in the porcine gastrointestinal tract. Peptides 12, 963-973 (1991).

Schmidt et al.: Substance P and Neurokinin A are codistributed and colocalized in the porcine gastrointestinal tract. Peptides 12, 963-973 (1991).

Lundberg LM. Growth and degeneration of uterine innervation. An experimental study in the guinea pig. Thesis Lund 1988.

For Research Use Only

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com

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