rev:   November 15, 2004

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  ANTIBODIES  

(anti-Human and others as indicated)

RDI Divison of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.


Mab to Endothelial Cells (veins)

cat#RDI-PRO10705     $375.00

Clone PAL-E


Category Mouse monoclonal, culture supernatant


Ig Class IgG2a


Immunogen Human melanoma cells


Clinical Application/ Specificity Antibody PAL-E shows a distinct positive staining of endothelial cells in all brain tumors (astrocytoma, oligodendroglioma, meningioma, medulloblastoma, ependymona). No reactivity with normal brain, in cases of encephalitis or gliosis. The antibody reacts with endothelial cells of capillaries, medium-sized or small veins, and venules; no reaction with endothelial cells of arteries, arterioles or those of lymphatics and sinusoids.


Recommended Positive Control for Endothelium

Application Ouchterlony

                   Immunohistochemistry

                   Suitable for frozen tissue

                   electron microscopy


Antigen Recoginzed Species (tested so far) :Human, goat, rabbit, pig

Working Dilution 1:10


Dilution Buffer PBS with 1% BSA and 0.1% Na-Azide


Incubation Time 1 h at room temperature


Storage At 4°C (undiluted) or at -20°C (aliquots)


Volume 1 ml

References

1. S. Leenstra, P.K. Das, D. Troost, D.A. Bosch, N. Claessen, A.E. Becker: PAL-E, monoclonal antibody with immunoreactivity for endothelium specific to brain tumours. Lancet Vol 335: 671

2. R.O. Schlingemann, G.M. Dingjan, J.J. Emeis, J. Blok, S.O. Warnaar, and D.J. Ruiter: Monoclonal Antibody PAL-E Specific for Endothelium. Lab Invest (1985) Vol. 52, No. 1:71-76.

Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics.

 see also relatedsee also   anti-LYVE-1,  anti-Podoplanin and  PROX-1 (Lymphatic endothelial cell markers)


RDI Divison of Fitzgerald Industries Intl

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com

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