rev:  May 3, 2002

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  ANTIBODIES  

(anti-Human and others as indicated)

RDI Divison of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.


ANTI-P16   (monoclonal and select polyclonals)  see also other anti-tumor related abs
Mab to p16

cat#RDI-PRO61074     $281.00/vial

Clone                         DCS-50.2
Category                    Mouse monoclonal
Form/Purification         Protein A chromatography
Ig Class                       IgG1
Immunogen                 Recombinant p16 protein

Clinical Application/

Specificity                   p16, a protein implicated in cancer, is a specific inhibitor for CDK4 and CDK6.

                                  It binds to phospho-rylated CDK-cyclin complex. p16 is lost in the majority of

                                  tumor cell lines and in most primary tu-mors. It is not expressed in melanoma.

                                 The antibody is especially useful for immunoprecipitation.

Application               · Immunoblotting

                                · Immunoprecipitation*

                                · Immunofluorescence

                                · Immunohistochemistry

                                · Flow cytometry*

· Suitable for frozen tissue and paraffin-embedded sections after microwave application

Antigen Recognized      Human

in Species (tested so far)

Working Dilution         After reconstitution with 1 ml dist. water, dilute 1:10 for immunohistochemistry
Dilution Buffer              PBS with 0.1% BSA

Storage/Stability          After reconstitution with 1 ml dist. water stable for min. 1 year when stored at 4°C

Quantity                      50 µg (lyoph.); contains 0.5% BSA and 0.01% NaN3 as preservative

For research use only, not for therapeutic or diagnostic use!


References

J. Lukas, D. Parry, L. Aagaard, D.J. Mann, J. Bartkova, M. Strauss, G. Peters & J. Bartek: Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature 375, 503-506


For In Vitro Research Use Only-Not For Use in Diagnostics


see also clones 16P04, JC4, JC8, 16P07, and rabbit polyclonal

also inquire for P15, P16, P18, P19, KIP2 p57, p27, p21 and other antibodies

RDI Divison of Fitzgerald Industries Intl

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com

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