rev: November 23, 2000

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  ANTIBODIES  

(anti-Human and others as indicated)

RDI Divison of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.


MONOCLONAL ANTIBODY: Rat anti-mouse NEUROPSIN

cat# RDI-NEUROPabrt      $469.00/vial   $438.00/vial 2+

Packaging: This antibody is lyophilized form. Prepare a stock solution by dissolving the lyophilized antibody in 100 uL of distilled water to make IgG1.0 mg/ml in PBS (pH7.2) / 1% Sucrose / 0.1% Sodium azide

Clone: MabB5

Isotype: Rat IgG2a

Immunogen: recombinant mouse neuropsin protein expressed in insect cells.

Specificity: This antibody detects 32kDa of mouse neuropsin on western blot from cell lystae from neuropsin overexpressed insect cell.

-western blot (approx 1-5ug/ml visualize band at 32Kd)

ref: -J. Neurosci 15:5088 (1995)

       -Brain Res, 728:116 (1996)

       -J Histochem Cytochem, 46:313 (1998)

       -Inoue, Net al., J Invest Dermatol 110:923 (1998)

Storage: Store at -20 DEG C. Avoid frequent warming cycles.

Background:Neuropsin is a trypsin-type, extracellular, serine   protease that was first cloned from mouse limbic brain as a factor related to neural plasticity. Physiological studies indicated that kindling stimulation induced neuropsin mRNA and its protease activity also increased in limbic areas during kindling and long-term potentiation. Subsequent study indicated that neuropsin mRNA localized not only in the limbic brain, but also in developing organs and adult keratinocytes. Recent immunohistochemical analysis demonstrated that neuropsin localized exclusively in the keratinizing epithelia of the epidermis and various stratified mucous membranes. During development, neuropsin was found in the various epithelia at embryonic days 14.5-15.5, prior to formation of the stratum corneum. Much stronger expression of neuropsin in nude mouse skin and mucous membranes than in normal mice. Those studies suggested that neuropsin is related to differentiation of keratinocytes and the process of keratogenesis.

For Research Use Only


RDI Divison of Fitzgerald Industries Intl

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com

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