rev: September 2, 1999

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  ANTIBODIES  

(anti-Human and others as indicated)

RDI Divison of researchd Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.


MMP-19 Antibodies

see also anti-MMP-1, MMP-2, MMP-3, MMP-7 , MMP-8, MMP-9 and MMP-13, MT1-MMP (MMP14) & MT2-MMP (MMP15)  & MT3-MMP (MMP16)


To date, human MMP proteins can be divided into 4 broad classes: collagenases, gelatinases, stromelysins, and membrane-type MMP's. As a family, the MMP's function at a neutral pH and are involved in a wide range of biological processes ranging from re-organization of tissue architecture to mediating tumor cell metastasis. MMP-19 (RASI-1) was originally PCR cloned from a liver cDNA library using EST primers (1). The full length protein consists of 508 amino acids with a predicted molecular weight of approximately 57 kDa for the zymogen form and maps to chromosome 12q14. As with other MMP family members the MMP-19 protein has a signal sequence, a prodomain with the characteristic conserved cysteine residue for maintaining latency, a zinc ion binding domain and a COOH terminus hemopexin domain .Unlike other MMP proteins however there is no fibronectin or transmembrane domain but instead an acidic residue rich domain near the "hinge" region. Based on these characteristics MMP-19 appears to define yet another class of MMP proteins. Expression of MMP-19 is elevated in rheumatoid arthritis where it co-localizes to the tunica media of blood vessel walls along with TIMP-1 .MMP-19 is the target of autoantibodies in rheumatoid arthritis and SLE
DATA SHEET: RABBIT anti-human MMP-19 POLYCLONAL

Catalog#: RDI-MMP19abR    Price: $438.00/vial

Package Size: 100ug in 1ml PBS with 0.1% sodium azizde and 0.2% gelatin.

Ig Isotype: Rabbit IgG

Antigen: amino acids 39-52 in pro-peptide of human MMP- 19

Reactivity: Binds to human MMP-19. (not rat or mouse)

Suitable for: western (2-3ug/ml), pos control HL-60 cells or HeLa cells, 2-3 hours RT or overnight 4 DEG C with chemiluminescence detection

-paraffin sections: 1ug/ml with ABC detection, pos control normal skin.

General Ref: J. Biol Chem 272:4281-4286 (1997)

                      Immunobiology 198 408-423 (1998)

Storage: Store 4-8 DEG C

It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.  


RDI Divison of researchd Industries Intl

San Jose, 95123 CA Snell ave 658

USA

phone (800) 370-2222

     or  (978) 371-6446 or (800) 370-2222

EMAIL:margaret@cellular-research.com

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