rev: April 15, 1998
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(anti-Human and others as indicated)
RDI Divison of Fitzgerald Industries Intl offers a wide line of antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.
see also anti-MMP-1, MMP-2, MMP-3, MMP-7 , MMP-8, MMP-9 and MMP-13, MT1-MMP (MMP14)
The MT2-MMP protein is encoded by a 3.6 kb mRNA species giving rise to a protein with a molecular weight of 68 kDa by SDS-PAGE. While it appears that MT1-MMP is responsible for cleaving progelatinase A (MMP-2, 72 kDa Type IV collagenase) to its active form , MT2-MMP plays a minor role in activation of proenzyme MMP-2 in breast carcinomas. However, coexpression of MT1-MMP and MT2-MMP in advanced stages of breast carcinomas suggests possible involvement of MT2-MMP in the metastasis.
Catalog#: RDI-MT2MMPabm Price: $438.00/vial
Package Size: 100ug (lyophilized)with 100ug BSA.
Dilution: Tighten cap, tap vial to settle contents. Reconstitute with 1ml sterile PBS pH 7.4 or sterile 20mM Tris-saline (20mM Tris containing 0.15M NaCl) pH 7.4. allow to set 2-3 hours at 4 DEG C, mix well. Addition of 0.1% sodium azide recommended or other preservative if suitable for your system (do not add azide if to be used in neutralization type reactions)
Ig Isotype: mouse IgG1
clone: Clone 162-22G
Antigen: oligopeptide of DTDNFQLPEDDLRG (residues 281-294) on mouse
Reactivity: Binds to human MT-MMP-2 (70kDa)
Suitable for: western blotting (approx 10ug/ml)using enhanced cheiluminescence detection, positive control HT-1080 cells.
-histochemistry (paraffin sections) 20ug/ml with breast carcinoma as positve control)
Ref: -Ueno, H et al (1997) Cancer Research 57:2055-2060
-Sato, H et al (1994) Nature 370:61-65
-Yu, M et al (1995) Cancer Res 55:3272-3277
Storage: Store 4 DEG C or lower. Avoid frequent freeze thaw cycles. Antibody is stable for at least 6 months when stored frozen undiluted and up to 1 month at 4 DEG C when neat or diluted as per above recommendation. Recommend adding 0.1% azide if suitable for your assay system. Dilution buffers should contain 0.1-1% BSA.
It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.
see also anti-MMP-1, MMP-2, MMP-3, MMP-7 ,MMP-8, MMP-9 and MMP-13
-For Research Use Only
34 Junction Square Drive
Concord MA 01742-3049
phone (800) 370-2222
or (978) 371-6446 or (800) 370-2222
fax (978) 371-2266
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