rev:  December 14, 2004

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(anti-Human and others as indicated)

RDI Divison of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.

see two ab below (CD222)
DATA SHEET: mouse anti-Mannose-6-Phosphate Receptor


Catalog#: RDI-MAN6Pabm   $469.00/vial

Package Size: 100ug in 0.1ml (1mg/ml)PBS with 0.05% sodium azide.

Species: mouse IgG2a


Hybridoma: fusion between myeloma cells and spleen cells from Balb/c mice immunized with purfied bovine 300kda CI-MPR.

Activity: Reacts with an epitope in the extracellular domain of human, monkey and bovine MPR by western blot (1ug/ml under NON-REDUCING conditions), immunofluorescence, EM immunohistochemistry and immunoprecipitation. Does not detect Chinese hamster ovary cell MPR.

Storage: Store at -20 DEG C.

References: -EMBO J, 9(1):77-84, 1990.

                    -J. Biol Chem 269(16):12159-12166, 1994

Background: Mannose 6-Phosphate Receptor (MPR) binds mannan-6-phosphate and it conatins a separate binding site for the type II insulin-like growth factor and is capable of binding both mannose-6-phosphate and IGF2 simultaneously. An approx 240kda soluble truncated form, representing the extracellular domain of the protein has also been found circulating in serum and is capable of binding both ligands. The steady state distribution of MPR's is predominantly within late endosomes, fewer in the trans Golgi network and approx 10% at cell surface.

Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics.

see also Mannose Binding lectin Elisa Kit  cat#RDI-M1990clb $688.00

-copyright by owner(s)

DATA SHEET: mouse anti-Human CD222   (Mannose-6-Phosphate Receptor)

Catalog#: RDI-CD222-238   $312.00/vial (Discontinued)

Package Size: 100ug in 0.2ml (0.5mg/ml)PBS with 0.09% sodium azide.

Species: mouse IgG1K

CLONE: Mem 238

Workshop VII #70640

Activity: Reacts with a 250 kDa type I transmembrane protein, also known as mannose-6-phosphate/insulin-like growth factor II-receptor (M6P/IGFII-R). It is expressed on monocytes and many other cell types.

Use: Flow cytometry on fixed and permeabilzed human cells (positive control human peripheral blood monocytes)

-not tested for other applications

Storage: Store at 4 DEG C.

References: 1. Godar S et al. Eur J Immunol 1999;29:1004.

                    2. Kang JX, et al. Proc Nat'lAcad Sci 1997;94:13671.

                     3. Kornfeld S. Ann Rev Biochem 1992;61:307.

Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics.

-copyright by owner(s)

RDI Divison of Fitzgerald Industries Intl

34 Junction Square Drive

Concord MA 01742-3049


phone (800) 370-2222

     or  (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

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