rev: November 3, 2003
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ANTIBODIES
(anti-Human and others as indicated)
RDI Divison of researchd Industries Intl offers a wide line of antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.
cat# RDI-GELSOLINabm $438.00/vial 50ug
RDI-GELSOLINabm-1 $750.00/vial 150ug
Background: Gelsolin was discovered several years ago becasue of its ability
to sever actin filaments in a CA+ dependent manner. The gene for gelsolin
encodes an 83 kDa protein that migrates as a 93 kDa polypeptide in SDS-gels.
The amino terminal domain contains the calcium independent actin severin
site whereas the calcium dependent site is located at the C terminal half
of the protein. Gelsolin exhibits significant homology with villin, another
calcium regulated actin filament severing protein. Gelsolin can be found
intracellularly as well as in a secreted form, however, it has been shown
that both forms are encoded by the same gene.
isotype: mIgG2a
package: 50ug (200ul) or 150ug (600ul) (at 0.25mg/ml in 50% glycerol, PBS
+ 1.5mM NaN3 & 1mg/ml BSA)
antigen: C-terminal protein fragment corresponding to amino acids 592-768
of human gelsolin
USe: Suitable for western blot on human using approx 0.1 ug/ml ab on total
cell lysate of A431 cells.. Major band =MW 93kDa.Immunoreactivity also shown
with dog, rat and mouse. Also suitable for immunoprecipitation ,
imunofluorescence and histochemistry (also tested on rabbit liver sections)
Storage: Store at -20 DEG C upon receipt. . Recommend aliquoting. Avoid frequent
warming cycles.
Main REF: -Kwiatkowski, D.J, et al, 1986 Nature 323:455
Precautions: For In vitro research Use Only. Not for use in or on humans
or animals or for diagnostics. It is the responsibility of the user to comply
with all local/state and Federal rules in the use of this product. We are
not responsible for any patent infringements that might result with the use
of or derivation of this product.
Also available: mono's and poly's against actin and others-see our antibody list at http://www.researchd.com/absort.htm or inquire.
RDI Divison of researchd Industries Intl
San Jose, 95123 CA Snell ave 658
USA
or 408-780-0908
EMAIL:margaret@cellular-research.com
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