rev:     November 3, 2003

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  ANTIBODIES  

(anti-Human and others as indicated)

RDI Divison of researchd Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.


GELSOLIN
Mouse anti-GELSOLIN Monoclonal ab

cat# RDI-GELSOLINabm         $438.00/vial 50ug

       RDI-GELSOLINabm-1      $750.00/vial 150ug


Background: Gelsolin was discovered several years ago becasue of its ability to sever actin filaments in a CA+ dependent manner. The gene for gelsolin encodes an 83 kDa protein that migrates as a 93 kDa polypeptide in SDS-gels. The amino terminal domain contains the calcium independent actin severin site whereas the calcium dependent site is located at the C terminal half of the protein. Gelsolin exhibits significant homology with villin, another calcium regulated actin filament severing protein. Gelsolin can be found intracellularly as well as in a secreted form, however, it has been shown that both forms are encoded by the same gene.


isotype: mIgG2a


package: 50ug (200ul) or 150ug (600ul) (at 0.25mg/ml in 50% glycerol, PBS + 1.5mM NaN3 & 1mg/ml BSA)


antigen: C-terminal protein fragment corresponding to amino acids 592-768 of human gelsolin


USe: Suitable for western blot on human using approx 0.1 ug/ml ab on total cell lysate of A431 cells.. Major band =MW 93kDa.Immunoreactivity also shown with dog, rat and mouse. Also suitable for   immunoprecipitation , imunofluorescence and histochemistry (also tested on rabbit liver sections)


Storage: Store at -20 DEG C upon receipt. . Recommend aliquoting. Avoid frequent warming cycles.


Main REF: -Kwiatkowski, D.J, et al, 1986 Nature 323:455


Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.

Also available: mono's and poly's against actin and others-see our antibody list at http://www.researchd.com/absort.htm or inquire.



RDI Divison of researchd Industries Intl

San Jose, 95123 CA Snell ave 658

USA

or (800) 370-2222

EMAIL:margaret@cellular-research.com

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