rev:    October 1, 2001

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  ANTIBODIES  

(anti-Human and others as indicated)

RDI Divison of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.

cat# RDI-FAKabm      $375.00/vial 50ug

       RDI-FAKabm-1    $625.00/vial 150ug

Background: FAK (focal adhesion kinase) is a novel protein tyrosine kinase that co-localizes with integrins in cellular focal adhesions. It is a major phosphotyrosine-containing protein in normal avian and rodent fibroblasts, but exhibits enhanced tyrosine phosphorylation in cells transformed by Rous sarcoma virus. Sequence analysis of cDNA encoding p125 FAK has revealed it to be the prototype of a new class of protein tyrosine kinases that is part of an integrin-regulated signal transduction pathway. FAK does not contain SH2 or SH3 domains, but it does possess a 159 amino acid carboxy terminal sequence (Focal Adhesion Targeting sequence) responsible for directing its cellular localization. p125 FAK is phosphorylated in response to fibronectin, as well as to extracellular adhesion matrix ligands. It appears that FAK may be primarily autophosphorylated and this modification may affect the interaction of FAK with other proteins. It has recently been shown that FAK can associate with pp60(src) in RSV transformed cells and with c-fyn in normal chicken embryo cells.

isotype: mIgG1

package: 50ug (200ul) or 150ug (600ul) (at 0.25mg/ml in 50% glycerol, PBS + 1.5mM NaN3 & 1mg/ml BSA)

antigen: a protein fragment corresponding to amino acids 354-533 from chicken FAK

Use: Suitable for western blot on human, dog, rat, chick and mouse under using approx 0.5ug/ml a on total cell lysate of human endothelial lysate. Major band =Mw 125kDa. Also suitable for histochemistry and immunofluorescence and immunoprecipitation (denaturing conditions)

Storage: Store at -20 DEG C upon receipt. Recommend aliquoting. Avoid frequent warming cycles.

-copyright by owner

Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (800) 370-2222

     or  (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com

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