rev: October 25, 1999
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(anti-Human and others as indicated)
RDI Divison of Fitzgerald Industries Intl offers a wide line of antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.
cat# RDI-EDNabm Price: $469.00/vial
Immunogen: purifie dprotein from human eosinophils
Specificity: This antibody detects human EDN (eosinophil-derived neurotoxin)on:
-western blot (approx 1ug/ml visualize band at 18-21 Kd)
(pos control human leukocytes)
ref: -J. Immunol., 137:2913(1986)
-J. Immunol., 143:2317 (1989)
Storage: Store at -20 DEG C. Avoid frequent warming cycles.
Background: Upon activation, eospinohils secrete several cationic proteins including major basic protein (MBP), eosinophil cationic protein (ECP) eosinophil peroxidase) and eosinophil derived neurotoxin (EDN). EDN, also called eosinophil protein X (EPX) is a glycosylated single chain protein with a molecular weight 18-21kDa and is a member of the ribonuclease A superfamily along with ECP. Although EDN has high sequence homology to ECP, EDN has 100 fold greater ribonuclease activity than ECP and nurotoxicity but not cytotoxicity. Eosinophil and its activation have been found to play an important role in inflammatory processes in allergic diseases. EDN can be a marker of eosinophil activation and degranulation.
For In Vitro Research Use Only
RDI Divison of Fitzgerald Industries Intl
34 Junction Square Drive
Concord MA 01742-3049
phone (978) 371-6446 or (800) 370-2222
fax (978) 371-2266
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