rev: October 25, 1999

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  ANTIBODIES  

(anti-Human and others as indicated)

RDI Divison of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.

cat# RDI-EDNabm     Price: $469.00/vial

Packaging: 100ug

Clone: 3H8

Isotype: mIgG2a

Immunogen: purifie dprotein from human eosinophils

Specificity: This antibody detects human EDN (eosinophil-derived neurotoxin)on:

-western blot (approx 1ug/ml visualize band at 18-21 Kd)

(pos control human leukocytes)

ref: -J. Immunol., 137:2913(1986)

      -J. Immunol., 143:2317 (1989)

Storage: Store at -20 DEG C. Avoid frequent warming cycles.

Background: Upon activation, eospinohils secrete several cationic proteins including major basic protein (MBP), eosinophil cationic protein (ECP) eosinophil peroxidase) and eosinophil derived neurotoxin (EDN). EDN, also called eosinophil protein X (EPX) is a glycosylated single chain protein with a molecular weight 18-21kDa and is a member of the ribonuclease A superfamily along with ECP. Although EDN has  high sequence homology to ECP, EDN has 100 fold greater ribonuclease activity than ECP and nurotoxicity but not cytotoxicity. Eosinophil and its activation have been found to play an important role in inflammatory processes in allergic diseases. EDN can be a marker of eosinophil activation and degranulation.

For In Vitro Research Use Only

RDI Divison of Fitzgerald Industries Intl

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com

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