rev: October 25, 1999
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ANTIBODIES
(anti-Human and others as indicated)
RDI Divison of researchd Industries Intl offers a wide line of antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.
cat# RDI-EDNabm Price: $469.00/vial
Packaging: 100ug
Clone: 3H8
Isotype: mIgG2a
Immunogen: purifie dprotein from human eosinophils
Specificity: This antibody detects human EDN (eosinophil-derived neurotoxin)on:
-western blot (approx 1ug/ml visualize band at 18-21 Kd)
(pos control human leukocytes)
ref: -J. Immunol., 137:2913(1986)
-J. Immunol., 143:2317 (1989)
Storage: Store at -20 DEG C. Avoid frequent warming cycles.
Background: Upon activation, eospinohils secrete several cationic proteins
including major basic protein (MBP), eosinophil cationic protein (ECP) eosinophil
peroxidase) and eosinophil derived neurotoxin (EDN). EDN, also called eosinophil
protein X (EPX) is a glycosylated single chain protein with a molecular weight
18-21kDa and is a member of the ribonuclease A superfamily along with ECP.
Although EDN has high sequence homology to ECP, EDN has 100 fold greater
ribonuclease activity than ECP and nurotoxicity but not cytotoxicity. Eosinophil
and its activation have been found to play an important role in inflammatory
processes in allergic diseases. EDN can be a marker of eosinophil activation
and degranulation.
For In Vitro Research Use Only
RDI Divison of researchd Industries Intl
San Jose, 95123 CA Snell ave 658
USA
or 408-780-0908
EMAIL:margaret@cellular-research.com
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