rev:  May 9, 2000

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  ANTIBODIES  

(anti-Human and others as indicated)

RDI Divison of researchd Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.

cat# RDI-DYSTROBabm        $375.00/vial 50ug

        RDI-DYSTROBabm-1    $625.00/vial 150ug

Background: Acetylcholine receptor clustering is considered an early   event and a marker for synaptogenesis between a motor neuron   and a muscle fiber. This process is mediated by the extracellular protein Agrin which binds to a and b Dystroglycan, previously discovered as Dystrobrevin- associated proteins. Dystrobrevin binds to the actin cytoskeleton by its N-terminal domain, thus providing the link between the actin cytoskeleton and receptor clustering. InTorpedo electric organ, Dystrobrevin is a prominent phosphotyrosine-containing protein. Murine Dystrobrevins comprise a family of four related proteins (1-4) with similar function, generated by alternative splicing. Dystrobrevin-1 is 688 amino acids and has an apparent mobility of 87kDa. Dystrobrevin-2 shares almost identical sequence with Dystrobrevin-1 in the first 500 amino acids and has an apparent mobility of 59kDa.

isotype: mIgG1

package: 50ug (200ul) or 150ug (600ul) (at 0.25mg/ml in 50% glycerol, PBS + 1.5mM NaN3 & 1mg/ml BSA)

antigen: a protein fragment corresponding to amino acids 249-903 from the MOUSE dystrobrevin sequence

Use: Suitable for western blot on rat using approx 0.5ug/ml ab on total cell lysate of rat brain lysate(positivecontrol) Major band =Mw 87Kda (additional bands approx 57kda). Also suitable for histochemistry( tested on rabbit cerebrum)

Storage: Store at -20 DEG C upon receipt. Recommend aliquoting. Avoid frequent warming cycles.

-copyright by owner

Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.

-copyright by owner

San Jose, 95123 CA Snell ave 658

USA

phone 408-780-0908

     or  (978) 371-6446 or 408-780-0908

EMAIL:margaret@cellular-research.com

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