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  ANTIBODIES  

(anti-Human and others as indicated)

RDI Divison of researchd Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.

ANTI-COMPLEMENT C5B neoepitope

see also anti-C3A,  anti-C3B-Alpha,  anti-C3b-Beta  , anti-C5, and anti-C5B neoepitope

Mab to Complement C5b  (neoepitope)  #RDI-PRO61022   $375.00/vial 50ug

                         cat#RDI-PRO61022-1X (no BSA/NO AZIDE) $2188.00/milligram

Clone Determination                    HCC 5b.1(neo)

Category                                       Mouse monoclonal

Immunoglobulin Class                  IgG1

Purification                                    SpAss-Protein A (recombinant)

Antigen                                          Activated human complement component C5

Specificity                                    HCC 5b.1(neo) allows detection of C5b-9 complexes via activated C5, especially in different forms of glomerulonephritis. Does not react with native C5!

Application Suitable for               frozen tissue

                                                     Immunoblotting (Western)

                                                    Cytological material

                                                      ELISA

Stability at 4°C                             one year after reconstitution

Quantity                                         50ug lyophilized with 0.5% BSA and 0.1% NaN3 (Bulk available without BSA).

Polypeptide Reacting ~MR 200 000 polypeptide of SDS denaturated complement component C5 and C5b of MR 185 000; after C5b activation, an MR 60 000 cleavage product also reacts (weakly)

Antigen Recognized in             Human primates, bovine, pig, goat

Species (tested so far)

Disorders Specifically Detected:    Detection of C5b-9 complexes via activated C5, whereas native C5 reacts with antibody HCC 5.1

Working Dilution                    When reconstituted with 1ml distilled water, dilute further 1:10

Incubation Time                      1h at RT

References

Moongkarndi, P., Dessauer, A., Brauch, H., Hänsch, G.M. and Rauterberg, E.W.: Immunological and functional properties of two monoclonal antibodies against human C5. Immunobiol. 165, 323 (1983)

Moongkarndi, P., Rauterberg, E.W., Kapp, A. and Katus, H.: Monoclonal antibodies against the fifth component of human complement. Immunobiol. 162, 397 (1982)

For Research Use Only

RDI Divison of researchd Industries Intl

San Jose, 95123 CA Snell ave 658

USA

or (800) 370-2222

EMAIL:margaret@cellular-research.com

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