rev: November 3, 2003
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(anti-Human and others as indicated)
RDI Divison of Fitzgerald Industries Intl offers a wide line of antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.
cat# RDI-CAVEO3abm $440.00/vial 50ug
RDI-CAVEO3amb-1 $750.00/vial 150ug
package: 50ug or 150ug purified antibody (0.25mg/ml) in a 50% glycerol, 20mM sodium phosphate pH7.5, 150mM NaCl, 1mg/ml BSA and 1.5mM sodium azide.
antigen: a fragment corresponding to amino acids 3-24 from the rat form of caveolin 3
Peptide sequence: T E E H T D L E A R I I K D I H C K E I D L
USe: Suitable for western blot on rat, mouse and rabbit using approx 0.1ug/ml ab on total cell rat muscle (using enhanced chemiluminescence detection, 2-3 hours RT or overnight at 4 DEG C.).Major band at Mw 18 kDa. Also suitable for immunofluorescence and histochemistry (positive control rabbit smooth muscle,)
Storage: Store at -20 DEG C upon receipt. Avoid frequent freeze thaw cycles. Recommend aliquoting. Avoid frequent freeze thaw cycles.
Main REF: Song, K. et al, 1996 J. Biol Chem 271:15160-15165
Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics.
also available control peptide: cat#RDI-CAVEO3-CPM $125.00/100ug $100.00/when ordered with antibody
It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.
cat# RDI-CAVEOL3abrX $469.00/100ul
Package: 100 ul(0.1mg/ml) of affinity purified rabbit serum with 1.0 mg/ml BSA and 0.05% sodium azide. Store at -20C. Avoid repeated freeze/thaw cycles.
Immunogen: Synthetic peptide: M(1) M T E E H T D L E A R I I K D I H(18) C
The immunizing peptide corresponds to amino acid residues 1-18 of human caveolin-3. This sequence is completely conserved in mouse caveolin-3. The immunizing peptide (Cat#RDI-CAVEOL3X-CP $156.00) is available for use in eutralization and control experiments.
Use: This polyclonal antibody detects caveolin-3 from rat tissues. This antibody does not detect caveolin-1 or -2. It has been successfully used in Western blot and immunoprecipitation procedures. By Western blot, this antibody detects an ~21 kDa protein representing caveolin-3 from rat heart homogenate.
Storage: Store at -20 DEG C upon receipt. Avoid frequent freeze thaw cycles. Recommend aliquoting. BEFORE OPENING, suggest centrifuging for 1 minute at 1000 RPM to concentrate material in vial.
References: J. Biol. Chem., 271: 2255-2261, 1996
Background: Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types
For Research Use Only
34 Junction Square Drive
Concord MA 01742-3049
phone (800) 370-2222
or (978) 371-6446 or (800) 370-2222
fax (978) 371-2266
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