rev: November 3, 2003
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ANTIBODIES
(anti-Human and others as indicated)
RDI Divison of researchd Industries Intl offers a wide line of antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.
-see also new FITC and TRITC conj Beta-Catenin abs
cat# RDI-ACateninabm $438.00/vial 50ug
RDI-ACateninabm-1 $750.00/vial
150ug
Background: The catenins (alpha, beta and gamma) are cytoplasmic proteins
which bind the highly conserved cytoplasmic tail of the E-Cadherin (also
known as uvomorulin) molecule. Alpha catenin was first identified as an
E-cadherin-associated protein; however it also appears to be able to interact
with other cadherin family members such as N-cadherin, and P-Cadherin. Increased
tyrosine phosphorylation of adherens junction proteins can disrupt
catenin-cadherin complexes, leading to changed in cell adhesion properties.
It has been noted that down regulation of this group of proteins often preceded
metastasis.Recent observations show a correlation between deletions within
the alpha cetenin gene and the development of prostate cancer.
isotype: mIgG1
package: 50ug or 150ug
antigen: a 19.4 kDa C-terminal fragment corresponding to amino acids 729-906
of the mouse alpha-catenin protein
Use: Suitable for western blot on human, dog, rat, mouse and chick, using
approx 1 to 0.04ug/ml ab on total cell lysate. Major band at Mw 102 kDa.
Also suitable for immunofluoresence
Storage: Store at -20 DEG C upon receipt. Avoid frequent freeze thaw cycles.
Recommend aliquoting. Avoid frequent freeze thaw cycles.
Main REF: Morton, R.A. et al 1993) Cancer Res. 53:3585
Hirano,S.
et al 1992) Cell 70:293
Precautions: For In vitro research Use Only. Not for use in or on humans
or animals or for diagnostics.It is the responsibility of the user to comply
with all local/state and Federal rules in the use of this product. We are
not responsible for any patent infringements that might result with the use
of or derivation of this product.
Also available:
monoclonal anti-Plakoglobin clone PG5.1 cat#RDI-CBL175 $438.00/50ug
monoclonal anti-Beta-catenin cat#RDI-BCATENINabm $438.00/50ug
monoclonal anti-gamma catenin cat#RDI-PLAKOabm $438.00/50ug
see also antibodies against cadherins
Mouse anti-Beta Catenin Monoclonal ab
cat# RDI-BCATENINabm $438.00/vial 50ug
RDI-BCATENINabm-1 $750.00/vial 150ug
RDI-BCATENIN-FT $438.00/vial 50ug FITC conjugated
RDI-BCATENIN-FT1 $812.00/vial 150ug FITC conjugated
RDI-BCATENIN-TRT $438.00/vial 50ug TRITC conj
RDI-BCATENIN-TRT1 $812.00/vial 150ug TRITC conj
RDI-BCATENIN-HRP $438.00/vial 50ug HRP conjugated
RDI-BCATENIN-HRP1
$812.00/vial 150ug HRP conj
Background: Beta catenin is a 92kDa protein which binds directly to the
cytoplasmic region of E-cadherin. Beta-catenin is similar to plakoglobin
(also known as gamma-catenin). The binding of beta-catenin seems to be required
for E-cadherin function since deletions in the cytoplasmic domain of E-cadherin
that eliminate catenin binding also result in a loss of cell adhesion. Recently,
an unexpected link between Beta catenin and colon cancer was described. Beta
catenin was found to co-immunoprecipitate with the APC tumor suppressor protein
in human colorectal tumor cell lines as well as in human kidney 293 cells.
E-Cadherin was not detectable in these complexes. This leads to the speculation
that the APC-catenin complex may be affecting the transmission of contact
inhibition signals and/or the regulation of cell adhesion.
isotype: mIgG1
package: 50ug or 150ug purified antibody (0.25mg/ml) in a 50% glycerol, 20mM
sodium phosphate pH7.5, 150mM NaCl, 1mg/ml BSA and 1.5mM sodium azide.
antigen: a 23 kDa protein fragment corresponding to residues 571-781 of mouse
Beta-catenin
Use: Suitable for western blot and immunofluorescence on human, dog, rat,
mouse and chick, using approx 1 to 0.5ug/ml ab on total cell lysate. Major
band at Mw 92 kDa. Suitable for immunoprecipitation at 2- 4ug/ml under native
or denaturing conditions ). Positive control HeLa cell lysate.
Storage: Store at -20 DEG C upon receipt. Avoid frequent freeze thaw cycles.
Recommend aliquoting. Avoid frequent freeze thaw cycles.
Main REF: Rubinfeld, B. et al. (1993) Science 262:1731
Su, L. -K et al. (1993) Science 262:1734
Precautions: For In vitro research Use Only. Not for use in or on humans
or animals or for diagnostics.
It is the responsibility of the user to comply with all local/state and Federal
rules in the use of this product. We are not responsible for any patent
infringements that might result with the use of or derivation of this product.
Also available:
monoclonal anti-Plakoglobin clone PG5.1 cat#RDI-CBL175 $438.00/50ug
monoclonals against alpha catenin and gamma catenin and various
cadherins (please inquire).
RDI Divison of researchd Industries Intl
San Jose, 95123 CA Snell ave 658
USA
phone 408-780-0908
or (978) 371-6446 or 408-780-0908
EMAIL:margaret@cellular-research.com
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