rev: November 3, 2003
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(anti-Human and others as indicated)
RDI Divison of Fitzgerald Industries Intl offers a wide line of antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.
cat# RDI-BARREST1abm $438.00/vial 50ug
RDI-BARREST1abm-1 $750.00/vial 150ug
Background: B arrestins were discovered by their ability to modulate the
interactions between the phosphorylated B2-Adrenergic receptors and G proteins.
This modulation resulted in a diminished B2-adrenergic receptor function,
also known as desensitization. Because arrestins are found at the synaptic
terminals, they may provide a termination mechanism that allows the neurons
to regain their original polarization and respond to a new neurotransmitter
stimulus. The C-terminal region of arrestins is involved in selecting the
phosphorylated and activated adrenergic receptors. The B-arrestin 1 gene
encodes for a protein of 418 amino acids with an approx molecular weight
of 55kDa. B-arrestin 1 is highly homologous to the 45kDa B-arrestin 2. Both
proteins are widely expressed, but are especially abundant in the central
package: 50ug (200ul) or 150ug (600ul) (at 0.25mg/ml in 50% glycerol, PBS + 1.5mM NaN3 & 1mg/ml BSA)
antigen: a protein fragment from aa 262-409 C term region rat B-arrestin 1
Use: Suitable for western blot on human, rat and mouse under using approx 1ug/ml ab on total cell lysate of mouse macrophages treated with IFN-G and LPS. Major band =Mw 55 kDa.
Storage: Store at -20 DEG C upon receipt. . Recommend aliquoting. Avoid frequent warming cycles.
Main REF: -Attramadal, H. et al. 1992 J. Biol. Chem 267:17882- 17890
-Gurevich, V.V. et al. 1995 J. Biol. Chem. 270:720-731
-copyright by owner
Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.
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