rev: April 9, 2002
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ANTIBODIES
(anti-Human and others as indicated)
RDI Divison of Fitzgerald Industries Intl offers a wide line of antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.
-Angiotensin II (ANG II) is an important physiological effector of blood pressure and volume regulation through vasoconstriction, aldosterone release, sodium uptake and thirst stimulation. Although ANG II interacts with two types of cell surface receptors, AT1 and AT2, the major cardiovascular effects appear to be mediated through AT1. Molecular cloning of the AT1 protein has shown it to be a member of the G protein-associated seven membrane transmembrane protein receptor family. AT1 receptors are expressed in the liver, kidney, aorta, lung, uterus, ovary, spleen, heart, adrenal and vascular smooth muscle. AT2 is highly expressed in myometrium with lower levels in adrenal and fallopian tube. It is also expressed at high levels in fetal kidney and intestine.
Angiotensin II mediates its action by interacting with membrane receptor, Angiotensin II type 1 receptors. The signal is transmitted via G-proteins hat activates a phosphatidylinositol-calcium second messenger system. ATII receptors are integral membrane proteins of approx. 359-363 AA and predicted to contain at least 7 transmembrane domains. The N and C-terminus are predicted to extracellular and cytoplasmic, respectively. Three isoforms of ATII receptors have been cloned. In rat type 1a (359 aa) is expressed in the liver kidney, aorta, lung, uterus, ovary, spleen, heart, adrenal and vascular smooth muscles (1). Rat Type 1b (also known as AT3; 359 aa) is found in liver, kidney, and aorta (2). Type 1c (177 aa) has been detected in brain, kidney, liver, spleen and lung (3). Human ATII type 2 363 aa G-coupled membrane receptor protein. It is highly expressed in adult myometrium and fetal kidney and intestine
cat#RDI-ANGIO2RXabCK $500.00/100ug vial
-chicken polyclonal antibody IgG, peptide affinity purified
-A 10 amino acid peptide sequence mapping near the N-terminus of rat AT II . This peptide is predicted to be extracellular. The peptide was coupled with KLH (carrier protein)
-The 10 AA rat AT12-P immungenic peptide is 100% identical in mouse, rat, human, pig, and rabbit. The sequence is the same in all AT II receptor isoforms (Type 1a, 1b, and 1c). It has no sequence homology with other G-protein coupled receptors. Actual crossreactivity of antibodies in all species is not established.
-mouse and human reactive
-suitable for western blotting (approx 1ug/ml with chemiluminescence detction ,band approx 55kda) and histochemistry (recommend acetone fixed frozens or PFA fixed sections, titer from 10ug/ml with ABC/DAB detection)
-control/blocking peptide: cat#RDI-ANGIO2RX-CX $188.00/100ug in 0.1ml PBS, pH 7.4 and 0.02% sodium merthiolate
cat#RDI-ANGIO2RXabR $500.00/100ug vial
-rabbit polyclonal antibody IgG, peptide affinity purified
-A 10 amino acid peptide sequence mapping near the N-terminus of rat AT II . This peptide is predicted to be extracellular. The peptide was coupled with KLH (carrier protein)
-The 10 AA rat immunogenic peptide is 100% identical in mouse, rat, human, pig, and rabbit. The sequence is the same in all AT II receptor isoforms (Type 1a, 1b, and 1c). It has no sequence homology with other G-protein coupled receptors. Actual crossreactivity of antibodies in all species is not established.
-mouse, rat, human , pig and rabbit reactive
-suitable for western blotting (approx 1ug/ml with chemiluminescence detction ,band approx 55kda) and histochemistry (recommend acetone fixed frozens or PFA fixed sections, titer from 10ug/ml with ABC/DAB detection)
-control/blocking peptide: cat#RDI-ANGIO2RXR-CX $188.00/100ug in 0.1ml PBS, pH 7.4 and 0.02% sodium merthiolate
cat#RDI-ANGIO2RX2abR $500.00/100ug vial
-rabbit polyclonal antibody IgG, peptide affinity purified
-An 18 amino acid peptide sequence mapping near the C-terminus of human AT II . This peptide is predicted to be cytoplasmic. The peptide was coupled with KLH (carrier protein)
-The 18 AA human immunogenic peptide is 88% identical in rat , 83% with mouse AT2 receptors. It has no sequence homology with other G-protein coupled receptors. Actual crossreactivity of antibodies in all species is not established.
-human, mouse,rat reactive
-suitable for western blotting (approx 1ug/ml with chemiluminescence detction ,band approx 45kda) and histochemistry (recommend acetone fixed frozens or PFA fixed sections, titer from 10ug/ml with ABC/DAB detection)
-control/blocking peptide: cat#RDI-ANGIO2RX2R-CX $188.00/100ug in 0.1ml PBS, pH 7.4 and 0.02% sodium merthiolate
cat#RDI-ANGIO2RX2abCK $500.00/100ul vial
-chicken polyclonal antibody IgG, peptide affinity purified
-An 18 amino acid peptide sequence mapping near the C-terminus of human AT II . This peptide is predicted to be cytoplasmic. The peptide was coupled with KLH (carrier protein)
-The 18 AA human immunogenic peptide is 88% identical in rat , 83% with mouse AT2 receptors. It has no sequence homology with other G-protein coupled receptors. Actual crossreactivity of antibodies in all species is not established.
-human, mouse,rat reactive
-suitable for western blotting (approx 1ug/ml with chemiluminescence detction ,band approx 45kda) and histochemistry (recommend acetone fixed frozens or PFA fixed sections, titer from 10ug/ml with ABC/DAB detection)
-control/blocking peptide: cat#RDI-ANGIO2RX2K-CX $188.00/100ug in 0.1ml PBS, pH 7.4 and 0.02% sodium merthiolate
For research use only. Not supplied for use in human diagnostic or therapeutic procedures
RDI Divison of Fitzgerald Industries Intl
34 Junction Square Drive
Concord MA 01742-3049
USA
phone (978) 371-6446 or (800) 370-2222
fax (978) 371-2266
EMAIL:antibodies@fitzgerald-fii.com
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