rev:       July 18, 2004

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  ANTIBODIES  

(anti-Human and others as indicated)

RDI Division of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.

Catalog Number: RDI-ALS24375      $312.00/100ug

                            RDI-ALS24375X   $1875.00/1mg

Lot Number:

Quantity: 100 ug in 100 ml (1 mg/ml) in PBS containing 0.02% sodium azide.

Description: Apoptosis in mammalian cells can be initiated through two major interrelated pathways, one involving engagement of the TNF family of death receptors, the other involving the release of cytochrome c from mitochondria. Unlike other members of the TNF ligand family, TNF-related apoptosis-inducing ligand (TRAIL) preferentially induces apoptosis in tumor cell lines, but not in normal cells, suggesting that TRAIL could potentially represent a powerful cancer therapeutic. Recent experiments have revealed that one of the key regulators of TRAIL expression in lymphocytes is the NF-kappa B transcription factors. Several TRAIL receptors have been identified: two of these receptors TRAIL-R1/DR4 and TRAIL-R2/DR5 contain cytoplasmic death domains and signal apoptosis, while two other decoy receptors, TRAIL-R3/DcR1 and TRAIL-R4/DcR2 lack a functional death domain and do not mediate apoptosis.

Host Species: Rabbit

Specificity: Residues with residues 280-296 (EHLLEPAEAERSQRRRL) of the human TRAIL-R2/DR5 protein.

Applications: Western blot - Use at 1:500 to 1:1,000 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Format: Affinity purified IgG

Storage: Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.

References: (1) Screaton,G.R. et al. (1997) Curr. Biol. 7 (9), 693-696.

                    (2) Baetu TM, and Hiscott J. Cytokine Growth Factor Rev. 2002 Jun;13(3):199-207.

For in vitro  research use only; not for use as a diagnostics.

RDI Division of Fitzgerald Industries Intl

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com

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