rev:       November 2, 2004

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  ANTIBODIES  

(anti-Human and others as indicated)

RDI Divison of researchd Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.

Catalog Number: RDI-ALS24357     $312.00/100ug

                            RDI-ALS24357X   $1875.00/1mg

Lot Number:

Quantity: 100ug in 100ul (1 mg/ml) in PBS containing 0.02% sodium azide.

Description: A novel primary response gene, Alivin 1 (ali1), is an activity-dependent gene and promotes survival of neurons. Sequence analyses reveal that rat, mouse, and human Ali1 proteins contain seven leucine-rich repeats, one IgC2-like loop and a transmembrane domain, and display homology to Kek and Trk families. Results suggest that expression of ali1 promotes depolarization-dependent survival of the granule neuron. Mouse ali1 was mapped to a locus approximately 55.3 cM from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12.

Host Species: Rabbit

Specificity: Reacts with residues 449-464 [TGDASADDRKAGKRVV] of mouse and rat Alivin 1. 81% sequence identity to human. Detects bands of 63 ands 66 kDa in brain with the majority of the immunoreactivity in the nuclear fraction.

Application: Western blot - Use at 1:500 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Format: Affinity purified IgG

Storage: Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.

Reference: Ono,T. et. al. J. Neurosci. 23 (13), 5887-5896 (2003).

For research use only; not for use as a diagnostic.

RDI Divison of researchd Industries Intl

San Jose, 95123 CA Snell ave 658

USA

or 408-780-0908

EMAIL:margaret@cellular-research.com

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