rev:         September 6, 2004

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(anti-Human and others as indicated)

RDI Divison of researchd Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.

Anti-Kos1 Polyclonal Antibody

Catalog Number: RDI-ALS24332    $312.0/100ug

                            RDI-ALS24332X  $1875.00/1mg

Lot Number:

Quantity: 100 ug in 100ul (1 mg/ml) in PBS containing 0.02% sodium azide.

Description: Kinase of embryonic stem cells (Kos1) is a nonreceptor protein tyrosine kinase (NRPTK) and a new member of the Ack family of NRPTKs. Kos1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Kos1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Kos1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.

Host Species: Rabbit

Specificity: Reacts with the C terminal residues 421-434 [QNQVQSLPAGSAEP] of the 47 kDa mouse Kos1 protein.

Applications: Western blot - Use at 1:500-1,000 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Format: Affinity purified IgG

Storage: Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.

Reference: Hoare, K. et al. Oncogene 22 (23), 3562-3577 (2003).

For research use only; not for use in or on humans or animals-not for use in diagnostics

RDI Divison of researchd Industries Intl

San Jose, 95123 CA Snell ave 658


or 408-780-0908

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