rev:       November 2, 2004

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  ANTIBODIES  

(anti-Human and others as indicated)

RDI Divison of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.

CLAC-P (collagen-like Alzheimer amyloid plaque componnet) see 2 abs below
Rabbit anti-Anti-CLAC-P (NC2-1 region) Polyclonal Antibody

Catalog Number: RDI-ALS24306      $312.00/100ug

                            RDI-ALS24306X   $1875.00/1mg

Lot Number:

Quantity: 100ug in 100ul (1 mg/ml) in PBS containing 0.02% sodium azide.

Description: Antibodies against senile plaque (SP) amyloid obtained a clone 9D2, which labeled amyloid fibrils in SPs and reacted with approximately 50/100 kDa polypeptides in Alzheimer's disease (AD) brains. The 9D2 antigen was identified as CLAC (collagen-like Alzheimer amyloid plaque component), and its precursor as CLAC-P/collagen type XXV. Both secreted and membrane-tethered forms of CLAC-P/collagen type XXV specifically bound to fibrillized Abeta, implicating these proteins in beta-amyloidogenesis and neuronal degeneration in AD.

Host Species: Rabbit

Specificity: Reacts with residues 171-183 [NHGFLSADQQLIK] of the NC2-1 region of human and mouse CLAC-P. Detects bands of 50, 70 and 100 kDa in SPs of AD brain, but not in diffuse plaques of non-demented aged individuals, diffuse deposits in sub-cortical structures and cerebellum in AD nor in cerebral amyloid angiopathy.

Application: Western blot - Use at 1:500 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Format: Affinity purified IgG

Storage: Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.

Reference: Hashimoto,T. et. al. EMBO J. 21 (7), 1524-1534 (2002).

For research use only; not for use as a diagnostic.

Anti-CLAC-P (NC2-2 region) Polyclonal Antibody

Catalog Number: RDI-ALS24307      $312.00/100ug

                            RDI-ALS24307X   $1875.00/1mg

Lot Number:

Quantity: 100ug in 100ul (1 mg/ml) in PBS containing 0.02% sodium azide.

Description: Antibodies against senile plaque (SP) amyloid obtained a clone 9D2, which labeled amyloid fibrils in SPs and reacted with approximately 50/100 kDa polypeptides in Alzheimer's disease (AD) brains. The 9D2 antigen was identified as CLAC (collagen-like Alzheimer amyloid plaque component), and its precursor as CLAC-P/collagen type XXV. Both secreted and membrane-tethered forms of CLAC-P/collagen type XXV specifically bound to fibrillized Abeta, implicating these proteins in beta-amyloidogenesis and neuronal degeneration in AD.

Host Species: Rabbit

Specificity: Reacts with residues 155-169 [KGEQGDQGPRMVFPK] of the NC2-2 region of human and mouse CLAC-P. Detects bands of 50, 70 and 100 kDa in SPs of AD brain, but not in diffuse plaques of non-demented aged individuals, diffuse deposits in sub-cortical structures and cerebellum in AD nor in cerebral amyloid angiopathy.

Application: Western blot - Use at 1:500 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Format: Affinity purified IgG

Storage: Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.

Reference: Hashimoto,T. et. al. EMBO J. 21 (7), 1524-1534 (2002).

For research use only; not for use as a diagnostic.

RDI Divison of Fitzgerald Industries Intl

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com

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