rev: February 16, 2005
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Human Cytokine/Growth Factor/Chemokines Sample Spec sheets (subject to change without notice):
also binds to mouse CD80/CD86
Background: Human CD152 (CTLA4)muIg is a cell surface glycoprotein expressed
at low levels on activated T cells. CD152 is a hgh affinity receptor for
the costimulatory molecules CD80 (B7-1) and CD86 (Bt-2) and appears to function
as a negative regulator of T cell activation. A soluble fusion protein combining
the extracellular (125aa) domain of human CD152 and murine IgG2a Fc(VTLA4
Igg) was developed.
cat# RDI-CD152FU-AG Price: $562.00/25ug
package: 25 micrograms (preservative free) in 63ul (0.4mg/ml) 50mM sodium
phosphate pH7.5, 100mM Potassium Chloride, 150mM NaCl.Product was filtered
through 0.1um and vialed under aseptic conditions. Tighten Cap and centrifuge
1 minute at 1000 rpm to concentrate material in vial prior to use.
Cell Line: BHK
Mw: a soluble 110kd dimeric fusion protein consisting of the extracellular
(125aa) domain of human CTLA-4 fused to murine IgG2a Fc.
Activity: This human CD152-muIg binds with high affinity to human or mouse
CD80 (B71) and CD86 (B7-2). CD152 Ig blocks the binding of anti-CD80
and anti-CD86 mabs.
-can be used in histochemistry (frozen sections) and flow cytometry
Storage: 2-5 DEG C (DO NOT FREEZE) aliquot and store in working aliquots.
For In Vitro Research Use Only.
also available:
conjugated to Biotin cat#RDI-CD152FUBT $594.00/25ug
FITC cat#RDI-CD152FUFT $750.00/50 tests
PE cat#RDI-CD152FUPE $938.00/50 tests
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